Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carbamazepine
Drug ID BADD_D00356
Description Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965.[A180301] Aside from the above uses, this drug is also given to control the symptoms of bipolar 1.[L1335] Interestingly, carbamazepine was the first anticonvulsant used to treat individuals with bipolar disorder.[A180319]
Indications and Usage For the treatment of epilepsy and pain associated with true trigeminal neuralgia.
Marketing Status Prescription; Discontinued
ATC Code N03AF01
DrugBank ID DB00564
KEGG ID D00252
MeSH ID D002220
PubChem ID 2554
TTD Drug ID D04MSM
NDC Product Code 60687-594; 51672-4123; 70518-3174; 67296-1637; 0781-5988; 68094-008; 0078-0509; 16571-682; 68084-561; 50090-5740; 68084-562; 0121-1894; 75834-221; 63629-8753; 70518-0181; 0904-7116; 68788-7825; 71335-0461; 51672-4047; 60505-2807; 60429-032; 50090-0384; 68071-4313; 0904-6172; 48087-0051; 70518-1769; 75834-220; 70518-2456; 68382-555; 42419-014; 29033-004; 30698-421; 16571-681; 16714-063; 0781-5987; 38779-0114; 50268-171; 70518-1433; 72189-157; 51927-2176; 54092-172; 13668-268; 51672-4124; 71930-072; 51552-0653; 70518-3176; 54092-173; 0615-3505; 0078-0508; 51672-4149; 35561-355; 65344-0028; 70518-1545; 0093-0090; 16714-065; 68382-557; 43063-328; 68788-7210; 0078-0512; 71930-073; 70518-3335; 68382-556; 71335-1730; 29033-019; 67386-621; 70518-3146; 70518-1436; 0781-8016; 51407-215; 49452-1705; 0832-6023; 43353-953; 70518-3266; 16714-064; 55154-1396; 76003-0251; 0078-0511; 0615-8125; 66993-409; 60505-2805; 60429-934; 51672-4150; 0093-0778; 17856-0407; 72664-218; 66993-407; 70518-2426; 51672-4151; 0832-6024; 63629-8255; 50090-2161; 70771-1469; 62512-0024; 70966-0020; 68094-007; 16571-680; 70518-2489; 60687-479; 70771-1470; 71205-025; 48087-0052; 35561-357; 51672-4005; 0121-1724; 13668-271; 60432-129; 71610-336; 60687-583; 63629-8743; 0121-0947; 70518-2841; 62991-1027; 35561-356; 0093-0109; 30698-419; 0904-6885; 70518-2653; 71930-074; 63552-060; 50090-4443; 63629-8721; 65372-1102; 71335-0691; 66993-408; 54092-171; 70771-1468; 63629-8720; 70518-2242; 0832-6022; 60505-0183; 60505-2806; 58118-0268; 0078-0510; 63629-8715; 51672-4041; 71335-0462; 50268-170; 29033-020; 0121-0862; 70518-0902; 50268-172; 0904-3854; 51672-4125; 30698-423
Synonyms Carbamazepine | Carbamazepine Acetate | Carbamazepine Dihydrate | Carbamazepine Hydrochloride | Carbamazepine L-Tartrate (4:1) | Carbamazepine Anhydrous | Carbamazepine Sulfate (2:1) | Carbazepin | Epitol | Finlepsin | Neurotol | Tegretol | Amizepine | Carbamazepine Phosphate
Chemical Information
Molecular Formula C15H12N2O
CAS Registry Number 298-46-4
SMILES C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Drug dependenceBifunctional epoxide hydrolase 2P34913T357348877250; 3146222; 8968658; 10380060
HepatotoxicityCytochrome P450 3A4P08684T378481575766; 8723729; 8347124
HypersensitivityEpoxide hydrolase 1P07099Not Available7503783; 7503784
Nephropathy toxicGlutathione hydrolase 1 proenzymeP19440Not Available8125216; 8457719; 1508841; 7785052; 15856183; 8494733; 8720036; 15223355
PorphyriaDelta-aminolevulinic acid dehydrataseQ5TJH2Not Available3181278; 6428897; 71507; 4067519; 3130256; 913061; 7120315; 463487; 4096716; 2500271; 6780356; 3813879; 2429498; 1165472; 6896622; 6800821
PorphyriaDelta-aminolevulinic acid dehydrataseP13716T205143181278; 6428897; 71507; 4067519; 3130256; 913061; 7120315; 463487; 4096716; 2500271; 6780356; 3813879; 2429498; 1165472; 6896622; 6800821
Renal impairmentBeta-2-microglobulinP61769T580803280573; 2679841; 6392147
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ammonia increased13.03.01.0230.000842%Not Available
Amnesia19.20.01.001; 17.03.02.0010.004210%
Anaemia01.03.02.001--
Anaemia macrocytic14.12.01.002; 01.03.02.0020.002105%Not Available
Anaemia megaloblastic14.12.01.003; 01.03.02.0030.000842%Not Available
Anal atresia03.04.06.001; 07.13.05.0010.000842%Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.0010.005472%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Aneurysm24.02.01.0010.000220%Not Available
Anger19.04.02.0010.002947%Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angioedema23.04.01.001; 10.01.05.0090.007156%Not Available
Angular cheilitis11.01.04.014; 07.05.07.013; 23.03.03.0540.000842%Not Available
Anorectal disorder07.03.01.0010.000842%Not Available
Anuria20.01.03.002--Not Available
Anxiety19.06.02.002--
Apathy19.04.04.0020.001684%Not Available
Apgar score low13.15.01.0120.000842%Not Available
Aphasia19.21.01.001; 17.02.03.0010.004631%
Aphthous ulcer07.05.06.0020.000842%Not Available
Aplasia cutis congenita03.05.01.011; 23.01.04.0040.000220%Not Available
Aplasia pure red cell01.03.03.001; 10.02.01.0030.002105%Not Available
Aplastic anaemia01.03.03.0020.000439%Not Available
Apnoea22.02.01.0010.003368%
Apraxia19.21.01.002; 17.02.03.0020.000842%Not Available
Areflexia17.02.01.0010.003789%Not Available
Arrhythmia02.03.02.0010.010524%Not Available
Arthralgia15.01.02.001--
Ascites09.01.05.003; 07.07.01.001; 02.05.04.002--
Aspartate aminotransferase increased13.03.01.0060.007577%
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