Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cabergoline
Drug ID BADD_D00329
Description Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Indications and Usage For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.
Marketing Status Prescription; Discontinued
ATC Code G02CB03; N04BC06
DrugBank ID DB00248
KEGG ID D00987
MeSH ID D000077465
PubChem ID 54746
TTD Drug ID D04EGX
NDC Product Code 40016-011; 49884-673; 14096-153; 50090-3951; 47848-009; 50742-118; 50090-3157; 59762-1005; 50090-5834; 0093-5420
Synonyms Cabergoline | 1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea | FCE 21336 | FCE-21336 | Cabaser | Cabaseril | Dostinex | Galastop | Cabergoline Diphosphate | 1-Ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
Chemical Information
Molecular Formula C26H37N5O2
CAS Registry Number 81409-90-7
SMILES CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Impulse-control disorder19.18.01.0020.066061%Not Available
Ischaemic stroke24.04.06.010; 17.08.01.0180.022020%Not Available
Neoplasm progression16.16.02.0050.037339%Not Available
Optic neuropathy06.02.08.002; 17.04.05.0050.022020%Not Available
Cardiac valve disease02.07.02.0010.088081%Not Available
Visual pathway disorder17.17.01.021; 06.02.08.0040.077071%Not Available
Decreased appetite08.01.09.028; 14.03.01.005--
Ill-defined disorder08.01.03.0490.022020%Not Available
Drug intolerance08.06.01.0130.077071%Not Available
Psychotic disorder19.03.01.0020.033030%
Congenital genitourinary abnormality21.15.02.002; 20.08.03.001; 03.06.02.002--Not Available
Autism spectrum disorder19.22.02.0020.022020%Not Available
Pulmonary arterial hypertension24.08.03.003; 22.06.01.0020.011489%Not Available
Hypersexuality19.08.03.0050.099091%Not Available
Treatment failure08.06.01.0170.008617%Not Available
Regurgitation07.01.07.004--Not Available
Type 2 diabetes mellitus14.06.01.003; 05.06.01.003--Not Available
Compulsive shopping19.06.05.0040.055051%Not Available
Foetal growth restriction18.03.01.0020.008617%
Posterior reversible encephalopathy syndrome17.13.02.0070.044040%
Substance-induced psychotic disorder19.03.01.007; 12.03.01.0530.033030%Not Available
Reversible cerebral vasoconstriction syndrome24.04.06.026; 18.06.01.004; 17.08.02.0140.088081%Not Available
Gambling disorder19.07.02.0140.088081%Not Available
Cartilage injury12.04.03.007; 15.07.03.0050.022020%Not Available
Cavernous sinus thrombosis24.01.04.015; 17.08.03.005; 11.01.03.0110.044040%Not Available
Empty sella syndrome05.03.04.0090.066061%Not Available
Hemianopia heteronymous17.17.01.023; 06.02.07.0060.022020%Not Available
Jealous delusion19.10.01.0060.044040%Not Available
Pneumocephalus17.02.05.060; 12.02.04.0090.209192%Not Available
Carotid aneurysm rupture24.02.04.002; 17.08.01.0440.066061%Not Available
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