| Pharmaceutical Information |
| Drug Name |
Butenafine |
| Drug ID |
BADD_D00321 |
| Description |
Butenafine hydrochloride is a synthetic benzylamine antifungal agent. Butenafine's mechanism of action is believed to involve the synthesis inhibition of sterols. In particular, butenafine acts to inhibit the activity of the squalene epoxidase enzyme that is essential in the formation of sterols necessary for fungal cell membranes. |
| Indications and Usage |
For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to M. furfur, interdigital tinea pedis (athlete’s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans. |
| Marketing Status |
Prescription; OTC; Discontinued |
| ATC Code |
D01AE23 |
| DrugBank ID |
DB01091
|
| KEGG ID |
D07596
|
| MeSH ID |
C067594
|
| PubChem ID |
2484
|
| TTD Drug ID |
D0B4DC
|
| NDC Product Code |
Not Available |
| Synonyms |
butenafine | Mentax | butenafine hydrochloride | N-4-tert-butylbenzyl-N-methyl-1-naphthalene methylamine hydrochloride | KP 363 | KP-363 |
|
| Chemical Information |
| Molecular Formula |
C23H27N |
| CAS Registry Number |
101828-21-1 |
| SMILES |
CC(C)(C)C1=CC=C(C=C1)CN(C)CC2=CC=CC3=CC=CC=C32 |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
| Dermatitis contact | 23.03.04.004; 12.03.01.040; 10.01.01.003 | - | - | Not Available | | Dysgeusia | 17.02.07.003; 07.14.03.001 | - | - | | | Erythema | 23.03.06.001 | - | - | Not Available | | Pain | 08.01.08.004 | - | - | | | Pruritus | 23.03.12.001 | - | - | |
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