| Drug Name |
Busulfan |
| Drug ID |
BADD_D00318 |
| Description |
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen. |
| Indications and Usage |
For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia (FDA has designated busulfan as an orphan drug for this use). It is also used as a component of pretransplant conditioning regimens in patients undergoing bone marrow transplantation for acute myeloid leukemia and nonmalignant diseases. |
| Marketing Status |
Prescription |
| ATC Code |
L01AB01 |
| DrugBank ID |
DB01008
|
| KEGG ID |
D00248
|
| MeSH ID |
D002066
|
| PubChem ID |
2478
|
| TTD Drug ID |
D07SUG
|
| NDC Product Code |
46014-1116; 72485-210; 50683-0363; 60505-6177; 71288-158; 51817-170; 48957-0010; 65219-160; 14096-147; 29902-0007; 67457-893; 0409-1112; 76388-713; 46439-8734; 0517-0920; 70121-1244; 59148-070; 72606-559; 25021-241; 69443-500; 16729-351; 63759-0008; 71288-116 |
| Synonyms |
Busulfan | Busulphan | Busulfan Wellcome | Wellcome, Busulfan | Busulfex | Myleran | Myléran | Myelosan | Mylecytan | n-Butane-1,3-di(methylsulfonate) | Glyzophrol |
