Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Bupivacaine hydrochloride
Drug ID BADD_D00309
Description Bupivacaine is a widely used local anesthetic agent.
Indications and Usage Bupivacaine is indicated for the production of local or regional anesthesia or analgesia for surgery, for oral surgery procedures, for diagnostic and therapeutic procedures, and for obstetrical procedures. Bupivacaine is indicated to induce post-surgical analgesia in adults for up to 72 hours following arthroscopic subacromial decompression by administration into the subacromial space under direct arthroscopic visualization.[L31423] Bupivacaine, together with the NSAID [meloxicam], is indicated for the production of postsurgical analgesia in adult patients for up to 72 hours following bunionectomy, open inguinal herniorrhaphy or total knee arthroplasty.[L34100]
Marketing Status approved; investigational
ATC Code N01BB01
DrugBank ID DB00297
KEGG ID D01450
MeSH ID D002045
PubChem ID 64737
TTD Drug ID D0A0FL
NDC Product Code 73293-0002; 82449-229; 0143-9328; 0143-9329; 0143-9330; 52584-160; 52584-465; 52584-467; 55150-167; 55150-169; 55150-170; 70594-114; 71288-723; 52584-466; 55150-171; 70529-007; 70594-117; 82449-224; 82449-226; 17381-074; 38779-0524; 55150-172; 0409-1160; 70529-008; 71288-726; 0404-9826; 0404-9906; 0409-1582; 0409-1610; 70594-115; 82449-227; 12651-111; 71277-0126; 51662-1396; 52584-560; 55150-250; 63323-466; 0409-1162; 0409-1163; 0409-1587; 76420-008; 82449-223; 82449-228; 52932-0729; 0143-9332; 52584-163; 0404-9907; 0404-9945; 71872-7133; 82449-225; 62991-2014; 55150-168; 0404-9827; 0404-9947; 0409-1159; 70529-006; 71351-022; 71872-7270; 61876-0726; 55150-249; 63323-464; 63323-472; 0404-9946; 0409-1560; 71872-7217; 76420-018; 76420-230; 51927-0244; 0143-9331; 0143-9334; 0143-9335; 0409-1165; 0409-1559; 70529-005; 70594-121; 82449-230; 66206-0126; 63323-465; 63323-467; 68788-8114; 70594-118; 70594-120; 49452-1313; 51927-2358; 55579-397; 63275-9993; 66064-1031; 36000-092; 0143-9333; 50090-4516; 55154-6970
UNII 7TQO7W3VT8
Synonyms Bupivacaine | 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide | Marcain | Bupivacain Janapharm | Bupivacain-RPR | Bupivacain RPR | Bupivacaina Braun | Carbostesin | Bupivacaine Carbonate | Bupivacaine Hydrochloride | Bupivacaine Monohydrochloride, Monohydrate | Buvacaina | Dolanaest | Sensorcaine | Svedocain Sin Vasoconstr | Marcaine | Bupivacaine Anhydrous
Chemical Information
Molecular Formula C18H29ClN2O
CAS Registry Number 18010-40-7
SMILES CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal labour18.07.02.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Anaesthesia17.02.06.036--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001--Not Available
Anxiety19.06.02.002--
Asthenia08.01.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Back pain15.03.04.005--
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac arrest02.03.04.001--
Cardiac output decreased13.14.02.001--Not Available
Chills15.05.03.016; 08.01.09.001--
Cranial nerve palsies multiple17.04.01.003--Not Available
Depression19.15.01.001--
Dizziness17.02.05.003; 02.11.04.006; 24.06.02.007--
Erythema23.03.06.001--Not Available
Forceps delivery25.10.02.001--Not Available
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypotension24.06.03.002--
Hypoventilation22.02.01.007--Not Available
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.003--
Meningism17.02.05.007--
Meningitis aseptic17.06.03.002; 11.01.03.002--Not Available
Miosis17.02.11.002; 06.05.03.003--Not Available
Monoplegia17.01.04.003--Not Available
Muscle contractions involuntary17.05.03.001; 15.05.03.008--Not Available
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