Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Brivaracetam
Drug ID BADD_D00297
Description Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam [A19184]. It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 [L760].
Indications and Usage Used as adjunctive therapy for partial-onset seizures in patients 16 years of age or older.
Marketing Status Prescription
ATC Code N03AX23
DrugBank ID DB05541
KEGG ID D08879
MeSH ID C482793
PubChem ID 9837243
TTD Drug ID D0CT4D
NDC Product Code 52076-6268; 50474-470; 69037-0055; 50474-370; 50474-870; 50474-670; 50474-770; 50474-570; 50474-970; 71666-007; 82608-003; 36998-0118; 69766-031; 16812-009
Synonyms brivaracetam | 2-(2-oxo-4-propylpyrrolidin-1-yl)butanamide | (2S)-2-((4R)-2-oxo-4-propylpyrrolidin-1-yl)butanamide | 1-pyrrolidineacetamide, alpha-ethyl-2-oxo-4-propyl-, (alphaS,4R)- | UCB 34714 | UCB34714 | UCB-34714 | Briviact
Chemical Information
Molecular Formula C11H20N2O2
CAS Registry Number 357336-20-0
SMILES CCCC1CC(=O)N(C1)C(CC)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Sedation17.02.04.0050.000507%Not Available
Seizure17.12.03.0010.016395%
Skin reaction23.03.03.013; 10.01.03.0190.000338%Not Available
Sleep disorder19.02.04.0010.000676%Not Available
Somnolence19.02.05.003; 17.02.04.0060.003380%
Status epilepticus17.12.03.0050.000338%Not Available
Suicidal ideation19.12.01.0030.002704%
Suicide attempt19.12.01.0040.000338%
Tearfulness19.15.02.005--Not Available
Thrombocytopenia01.08.01.0020.000338%Not Available
Ventricular fibrillation02.03.04.0080.000338%
Vertigo04.04.01.003; 17.02.12.002--
Vomiting07.01.07.003--
Weight decreased13.15.01.0050.000507%
Weight increased13.15.01.0060.000338%
Balance disorder17.02.02.007--Not Available
Affect lability19.04.01.001--Not Available
Myoclonic epilepsy17.12.03.0070.000338%Not Available
Partial seizures17.12.03.0100.000507%Not Available
Abnormal behaviour19.01.01.001--Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.000676%
Psychiatric symptom19.01.02.001--Not Available
Adjustment disorder19.23.01.001--Not Available
Disease progression08.01.03.0380.000265%
Drug intolerance08.06.01.0130.000338%Not Available
Psychotic disorder19.03.01.0020.000338%
Sudden unexplained death in epilepsy17.12.03.019; 08.04.01.0120.000088%Not Available
Seizure cluster17.12.03.0290.000338%Not Available
Change in seizure presentation17.12.03.0220.000338%Not Available
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