Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bosutinib
Drug ID BADD_D00286
Description Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Compared to other tyrosine kinase inhibitors, it has a more favourable hematologic toxicity profile. FDA approved on September 4, 2012.
Indications and Usage Treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapy in adult patients.
Marketing Status Not Available
ATC Code L01EA04
DrugBank ID DB06616
KEGG ID D03252
MeSH ID C471992
PubChem ID 5328940
TTD Drug ID D0OB0F
NDC Product Code 54893-0042; 54893-0048; 54893-0041; 46708-878
Synonyms bosutinib | SKI606 | SKI-606
Chemical Information
Molecular Formula C26H29Cl2N5O3
CAS Registry Number 380843-75-4
SMILES CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rash macular23.03.13.0030.001066%Not Available
Rash maculo-papular23.03.13.0040.000533%
Rash papular23.03.13.0170.001598%Not Available
Rash pruritic23.03.12.0020.002664%Not Available
Rash vesicular23.03.13.0090.000533%Not Available
Red blood cell count decreased13.01.05.0070.002398%Not Available
Renal disorder20.01.02.0020.002931%Not Available
Renal failure20.01.03.0050.000903%Not Available
Renal pain20.02.03.0030.000533%Not Available
Respiratory failure14.01.04.003; 22.02.06.002--
Retching07.01.07.0020.000799%Not Available
Rheumatoid arthritis15.01.03.001; 10.04.06.0010.000533%Not Available
Scab23.03.03.0040.000533%Not Available
Sciatica17.10.03.001; 15.10.01.0010.000533%Not Available
Second primary malignancy16.16.01.0140.001320%
Seizure17.12.03.001--
Sepsis11.01.11.003--
Sinusitis22.07.03.007; 11.01.13.0050.001332%
Skin discolouration23.03.03.0050.001865%Not Available
Skin disorder23.03.03.0070.001332%Not Available
Skin exfoliation23.03.07.003--Not Available
Skin lesion23.03.03.0100.000533%Not Available
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder17.02.08.003; 22.02.05.034; 19.19.02.002--Not Available
Splenomegaly01.09.02.0010.000533%Not Available
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.0200.000799%
Stress19.06.02.004--Not Available
Subdural haematoma17.08.05.002; 24.07.04.005; 12.01.10.003--Not Available
Swelling08.01.03.015--Not Available
Swelling face23.04.01.018; 10.01.05.0180.001598%Not Available
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