Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bosutinib
Drug ID BADD_D00286
Description Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Compared to other tyrosine kinase inhibitors, it has a more favourable hematologic toxicity profile. FDA approved on September 4, 2012.
Indications and Usage Treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapy in adult patients.
Marketing Status Not Available
ATC Code L01EA04
DrugBank ID DB06616
KEGG ID D03252
MeSH ID C471992
PubChem ID 5328940
TTD Drug ID D0OB0F
NDC Product Code 54893-0042; 54893-0048; 54893-0041; 46708-878
Synonyms bosutinib | SKI606 | SKI-606
Chemical Information
Molecular Formula C26H29Cl2N5O3
CAS Registry Number 380843-75-4
SMILES CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pain in extremity15.03.04.010--
Palpitations02.01.02.003--
Pancreatic carcinoma07.21.09.002; 16.13.10.0010.000208%Not Available
Pancreatitis07.18.01.0010.001598%
Pancreatitis acute07.18.01.002--Not Available
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.005--
Paralysis17.01.04.0040.000533%Not Available
Pericardial effusion02.06.01.0020.003996%
Pericarditis02.06.02.0010.000533%
Pharyngitis07.05.07.004; 22.07.03.004; 11.01.13.0030.000533%
Photosensitivity reaction23.03.09.0030.000533%
Platelet count decreased13.01.04.0010.004263%
Pleural effusion22.05.02.0020.013853%
Pneumonia22.07.01.003; 11.01.09.0030.010124%Not Available
Pneumonia aspiration22.01.01.0050.000278%Not Available
Pneumonitis22.01.01.0060.001066%
Pollakiuria20.02.02.007--
Proctalgia07.03.02.0010.000533%
Productive cough22.02.03.0050.000799%
Protein total increased13.09.01.0050.000533%Not Available
Prurigo23.03.04.017--Not Available
Pruritus23.03.12.0010.008525%
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pulmonary hypertension24.08.03.002; 22.06.01.0010.000764%
Pulmonary oedema02.05.02.003; 22.01.03.0030.002931%
Pyrexia08.05.02.0030.009324%
Rash23.03.13.0010.037298%Not Available
Rash erythematous23.03.06.0030.001066%Not Available
Rash generalised23.03.13.0020.001865%Not Available
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