Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bosutinib
Drug ID BADD_D00286
Description Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Compared to other tyrosine kinase inhibitors, it has a more favourable hematologic toxicity profile. FDA approved on September 4, 2012.
Indications and Usage Treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapy in adult patients.
Marketing Status Not Available
ATC Code L01EA04
DrugBank ID DB06616
KEGG ID D03252
MeSH ID C471992
PubChem ID 5328940
TTD Drug ID D0OB0F
NDC Product Code 54893-0042; 54893-0048; 54893-0041; 46708-878
Synonyms bosutinib | SKI606 | SKI-606
Chemical Information
Molecular Formula C26H29Cl2N5O3
CAS Registry Number 380843-75-4
SMILES CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypokalaemia14.05.03.002--
Hyponatraemia14.05.04.002--
Hypophosphataemia14.04.03.001--
Hypotension24.06.03.002--
Hypoxia22.02.02.003--
Immune system disorder10.02.01.001--Not Available
Impaired gastric emptying07.02.02.0040.000533%
Incontinence17.05.01.006; 07.01.06.011; 20.02.02.0040.000533%Not Available
Infection11.01.08.0020.000764%Not Available
Influenza22.07.02.001; 11.05.03.0010.002664%Not Available
Influenza like illness08.01.03.010--
Insomnia19.02.01.002; 17.15.03.002--
Interstitial lung disease22.01.02.003; 10.02.01.0330.001865%Not Available
Iron deficiency14.13.02.0020.000799%Not Available
Iron deficiency anaemia14.13.02.001; 01.03.01.0020.000533%Not Available
Joint swelling15.01.02.0040.002131%Not Available
Laboratory test abnormal13.18.01.001--Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukocytosis01.02.01.0020.000533%
Leukopenia01.02.02.001--Not Available
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.0050.001332%Not Available
Lipase increased13.05.01.0030.000799%
Liver disorder09.01.08.0010.002664%Not Available
Liver function test abnormal13.03.01.0130.001066%Not Available
Localised infection11.01.08.0060.000799%Not Available
Long QT syndrome02.03.01.017--Not Available
Loss of consciousness17.02.04.004--Not Available
Lower respiratory tract infection22.07.01.002; 11.01.09.002--Not Available
Lung disorder22.02.07.001--Not Available
Lymphoma16.20.01.001; 01.12.01.0010.000139%Not Available
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