Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bosutinib
Drug ID BADD_D00286
Description Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Compared to other tyrosine kinase inhibitors, it has a more favourable hematologic toxicity profile. FDA approved on September 4, 2012.
Indications and Usage Treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapy in adult patients.
Marketing Status Not Available
ATC Code L01EA04
DrugBank ID DB06616
KEGG ID D03252
MeSH ID C471992
PubChem ID 5328940
TTD Drug ID D0OB0F
NDC Product Code 54893-0042; 54893-0048; 54893-0041; 46708-878
Synonyms bosutinib | SKI606 | SKI-606
Chemical Information
Molecular Formula C26H29Cl2N5O3
CAS Registry Number 380843-75-4
SMILES CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.0010.007726%
Cough22.02.03.0010.005595%
Death08.04.01.001--
Decreased activity08.01.01.006; 19.11.01.0020.000533%Not Available
Dehydration14.05.05.0010.005861%
Depressed mood19.15.02.001--Not Available
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis allergic23.03.04.003; 10.01.03.0140.000533%Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.0040.000533%
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.0010.136669%
Diarrhoea haemorrhagic24.07.02.004; 07.02.01.0020.000533%Not Available
Discomfort08.01.08.003--Not Available
Disturbance in attention19.21.02.002; 17.03.03.001--
Diverticulitis11.01.07.003; 07.10.02.0010.001066%Not Available
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.015--Not Available
Drug hypersensitivity10.01.01.001--Not Available
Dry mouth07.06.01.0020.001598%
Dry skin23.03.03.0010.001598%
Dysgeusia17.02.07.003; 07.14.03.0010.001865%
Dyspepsia07.01.02.0010.003463%
Dysphagia07.01.06.0030.002664%
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.0040.001066%
Dyspnoea02.01.03.002; 22.02.01.0040.014386%
Dyspnoea exertional22.02.01.005; 02.01.03.0030.001332%Not Available
Dysuria20.02.02.0020.000799%
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