Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bivalirudin
Drug ID BADD_D00279
Description Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important to monitor changes in hematocrit, activated partial thromboplastin time, international normalized ratio and blood pressure.
Indications and Usage For treatment of heparin-induced thrombocytopenia and for the prevention of thrombosis. Bivalirudin is indicated for use in patients undergoing percutaneous coronary intervention (PCI), in patients at moderate to high risk acute coronary syndromes due to unstable angina or non-ST segment elevation in whom a PCI is planned.
Marketing Status Prescription
ATC Code B01AE06
DrugBank ID DB00006
KEGG ID D03136
MeSH ID C074619
PubChem ID 16129704
NDC Product Code 0781-3447; 63323-562; 72572-035; 55111-652; 65129-1225; 71288-427; 70436-025; 55463-0029; 52958-112; 0781-3158; 41524-0001; 0781-9158; 16729-275; 36974-0066; 0409-8300; 32861-0001; 70860-403; 70860-402; 68225-041; 55111-918; 52958-034; 55150-210; 76177-001; 67457-256; 70511-141; 0781-3453
Synonyms bivalirudin | Phe-Pro-Arg-Pro-(Gly)4-desulfohirudin-(53-64) | Phe-Pro-Arg-Pro-(Gly)4 desulfato-Tyr63'-hirugen | Phe-Pro-Arg-Pro-(Gly)4-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu | CTB-001 | Hirulog | Hirulog-1 | Angiomax | BG 8967 | BG8967 | BG-8967
Chemical Information
Molecular Formula C98H138N24O33
CAS Registry Number 128270-60-0
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acute myocardial infarction24.04.04.001; Available
Anaphylactic reaction10.01.07.001;
Anaphylactic shock24.06.02.004; Available
Angina pectoris24.04.04.002;
Arteriovenous fistula24.03.03.001--Not Available
Atrial fibrillation02.03.03.002--
Back pain15.03.04.005--
Blood pressure decreased13.14.03.0020.000371%Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.000371%Not Available
Cardiac arrest02.03.04.0010.000290%
Cardiac tamponade02.06.01.001--
Cardio-respiratory arrest02.03.04.002; Available
Cardiogenic shock24.06.02.006; Available
Cerebral haemorrhage24.07.04.001; Available
Cerebral ischaemia24.04.06.003;
Cerebrovascular accident24.03.05.001;
Chest pain02.02.02.011;; Available
Coagulation time prolonged13.01.02.0060.001298%Not Available
Coagulation time shortened13.01.02.0230.001298%Not Available
Coagulopathy01.01.02.001--Not Available
Compartment syndrome24.04.05.006; Available
Confusional state19.13.01.001;
Coronary artery occlusion24.04.04.013; Available
Coronary artery thrombosis24.01.05.002; Available
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