Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol
Drug ID BADD_D00277
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage For management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI).
Marketing Status Prescription; Discontinued
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D02342
MeSH ID D017298
PubChem ID 2405
TTD Drug ID D0K3ZR
NDC Product Code Not Available
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C18H31NO4
CAS Registry Number 66722-44-9
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Aortic dissection24.02.03.0020.001342%Not Available
Aortic valve incompetence02.07.03.0010.000525%Not Available
Apathy19.04.04.0020.002013%Not Available
Aphasia19.21.01.001; 17.02.03.0010.006038%
Arrhythmia02.03.02.0010.018113%Not Available
Arrhythmia supraventricular02.03.03.0010.001342%Not Available
Arterial thrombosis24.01.01.002--Not Available
Arteriospasm coronary24.04.04.005; 02.02.02.0050.002013%Not Available
Arthralgia15.01.02.001--
Arthropathy15.01.01.003--Not Available
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.005367%
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.0010.028846%Not Available
Asthma22.03.01.002; 10.01.03.0100.002683%Not Available
Ataxia17.02.02.001; 08.01.02.0040.001342%
Atrial fibrillation02.03.03.0020.025492%
Atrial flutter02.03.03.0030.002013%
Atrial septal defect03.07.02.002; 02.04.02.0090.009392%Not Available
Atrioventricular block02.03.01.0020.023480%Not Available
Atrioventricular block complete02.03.01.0030.018113%
Atrioventricular block first degree02.03.01.0040.010734%
Atrioventricular block second degree02.03.01.0050.007379%
Auditory disorder04.02.03.002--Not Available
Back pain15.03.04.005--
Basal cell carcinoma23.08.02.001; 16.03.02.0010.008050%Not Available
Bladder pain20.02.02.001--Not Available
Blepharospasm17.17.02.001; 06.05.01.0010.001342%Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Blood bilirubin increased13.03.01.0080.004696%
Blood cholesterol increased13.12.01.0020.002013%
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