Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol
Drug ID BADD_D00277
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage For management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI).
Marketing Status Prescription; Discontinued
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D02342
MeSH ID D017298
PubChem ID 2405
TTD Drug ID D0K3ZR
NDC Product Code Not Available
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C18H31NO4
CAS Registry Number 66722-44-9
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Decreased appetite08.01.09.028; 14.03.01.0050.012746%
Erectile dysfunction21.03.01.007; 19.08.04.0010.002683%
Purine metabolism disorder14.09.01.007--Not Available
Renal function test abnormal13.13.01.0120.001342%Not Available
Respiratory disorder neonatal22.11.01.002; 18.04.09.0020.004696%Not Available
Ill-defined disorder08.01.03.049--Not Available
Inner ear disorder04.04.02.002--Not Available
Lacrimal disorder06.08.02.005--Not Available
Sensation of foreign body08.01.09.0020.002683%Not Available
Ulcer haemorrhage24.07.01.040; 08.03.06.0030.002013%Not Available
Drug intolerance08.06.01.013--Not Available
Hepatobiliary disease09.01.08.003--Not Available
Renal impairment20.01.03.0100.010734%Not Available
Respiratory tract infection22.07.07.001; 11.01.08.0170.001342%Not Available
Cystitis noninfective20.03.02.001--
Renal aplasia20.01.02.001; 03.06.01.0020.001342%Not Available
Low birth weight baby18.04.02.0030.005367%Not Available
Hypertransaminasaemia09.01.02.0050.001342%Not Available
Oropharyngeal discomfort22.02.05.027; 07.05.05.008--Not Available
Oropharyngeal pain22.02.05.022; 07.05.05.004--
Myocardial depression02.04.02.0150.001342%Not Available
Acute kidney injury20.01.03.0160.040251%
Foetal growth restriction18.03.01.0020.002683%
Respiratory tract oedema22.02.07.013--Not Available
Toxicity to various agents12.03.01.046--Not Available
Drug-induced liver injury09.01.07.023; 12.03.01.044--Not Available
Peripheral artery stenosis24.04.03.0170.001342%Not Available
Hepatocellular carcinoma16.07.02.005; 09.04.02.010--Not Available
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.0210.005367%Not Available
Language disorder19.19.01.006; 17.02.08.0150.002013%Not Available
The 19th Page    First    Pre   19 20    Next   Last    Total 20 Pages