Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol
Drug ID BADD_D00277
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage For management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI).
Marketing Status Prescription; Discontinued
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D02342
MeSH ID D017298
PubChem ID 2405
TTD Drug ID D0K3ZR
NDC Product Code Not Available
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C18H31NO4
CAS Registry Number 66722-44-9
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haemorrhage24.07.01.002--Not Available
Cutaneous lupus erythematosus15.06.02.007; 10.04.03.007; 23.03.02.0080.002013%Not Available
Body height decreased13.15.01.0290.001342%Not Available
Paraesthesia oral17.02.06.008; 07.05.03.0030.001342%Not Available
Cognitive disorder17.03.03.003; 19.21.02.001--
Toxic skin eruption23.03.05.003; 10.01.01.0080.004025%Not Available
Troponin I increased13.04.01.0050.001342%
Disturbance in sexual arousal19.08.04.003--Not Available
Brugada syndrome02.03.01.0130.001342%Not Available
Congenital eye disorder06.08.03.011; 03.01.01.002--Not Available
Juvenile idiopathic arthritis15.01.03.004; 10.04.06.0040.001342%Not Available
Angiopathy24.03.02.007--Not Available
Urine output increased13.13.03.002--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
Hot flush21.02.02.001; 08.01.03.027; 24.03.01.005--
Ventricular failure02.05.01.0070.002683%Not Available
Appetite disorder19.09.01.002; 14.03.01.0040.002683%Not Available
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Electrocardiogram change13.14.05.0140.001342%Not Available
Feeding disorder19.09.01.003; 14.03.02.0030.002013%Not Available
Embolism24.01.01.009--
Intervertebral disc degeneration15.10.01.0020.001342%Not Available
Intracranial venous sinus thrombosis24.01.04.012; 17.08.03.0030.001342%Not Available
Ischaemia24.04.02.004--Not Available
Ischaemic stroke24.04.06.010; 17.08.01.018--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Sudden hearing loss04.02.01.0090.004696%Not Available
The 18th Page    First    Pre   18 19 20    Next   Last    Total 20 Pages