Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Biperiden hydrochloride
Drug ID BADD_D00275
Description A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.
Indications and Usage For use as an adjunct in the therapy of all forms of parkinsonism and control of extrapyramidal disorders secondary to neuroleptic drug therapy.
Marketing Status Discontinued
ATC Code N04AA02
DrugBank ID DB00810
KEGG ID D02246
MeSH ID D001712
PubChem ID 92151
TTD Drug ID D0B4TN
NDC Product Code Not Available
Synonyms Biperiden | Biperidene | alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol | Biperiden, 1S-(1 alpha,2 alpha(R*),4 alpha)-Isomer | Biperiden, 1R-(1 alpha,2 alpha(R*),4 alpha)-Isomer | Akineton | Biperiden Hydrochloride | Hydrochloride, Biperiden
Chemical Information
Molecular Formula C21H30ClNO
CAS Registry Number 1235-82-1
SMILES C1CCN(CC1)CCC(C2CC3CC2C=C3)(C4=CC=CC=C4)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation17.02.05.012; 19.06.02.001--
Anticholinergic syndrome17.05.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Chorea17.01.01.001--Not Available
Constipation07.02.02.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dry mouth07.06.01.002--
Euphoric mood19.04.02.006--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Rapid eye movements sleep abnormal19.02.03.004; 17.15.04.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Urinary retention20.02.02.011--
Vision blurred17.17.01.010; 06.02.06.007--
Abnormal behaviour19.01.01.001--Not Available
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