Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bicalutamide
Drug ID BADD_D00271
Description Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor.
Indications and Usage For treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.
Marketing Status Prescription; Discontinued
ATC Code L02BB03
DrugBank ID DB01128
KEGG ID D00961
MeSH ID C053541
PubChem ID 2375
TTD Drug ID D0V9BD
NDC Product Code 60429-177; 70518-2993; 51846-1028; 16714-816; 62559-680; 0904-6019; 16729-023; 43265-0705; 15308-0360; 54893-0001; 49711-1504; 65841-613; 43265-7195; 49711-1509; 71205-577; 68382-224; 47335-485; 63629-8308; 63759-0004; 62559-890; 53104-7664; 46014-1111; 58623-0068
Synonyms bicalutamide | 4'-cyano-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methyl-3'-(trifluoromethyl)propionanilide | Casodex | Cosudex | ICI-176334 | ICI 176334
Chemical Information
Molecular Formula C18H14F4N2O4S
CAS Registry Number 90357-06-5
SMILES CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Facial bones fracture15.08.04.001; 12.04.05.0020.006444%Not Available
Fat tissue increased08.01.03.0090.006444%Not Available
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.002--
Feeling abnormal08.01.09.014--Not Available
Feeling hot08.01.09.0090.019333%Not Available
Femur fracture15.08.03.003; 12.04.01.003--Not Available
Flatulence07.01.04.002--
Fracture15.08.02.001; 12.04.02.001--
Gait disturbance17.02.05.016; 08.01.02.002--
Gastric cancer07.21.02.001; 16.13.03.0010.004203%Not Available
Gastritis07.08.02.001--
Gastrointestinal carcinoma16.13.04.001; 07.21.03.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Glucose tolerance decreased13.02.02.004--Not Available
Glucose tolerance impaired14.06.02.001; 05.06.02.0010.009667%
Glycosuria20.02.01.0050.002522%
Glycosylated haemoglobin increased13.02.02.0050.012889%Not Available
Gout14.09.01.001; 15.01.06.001--Not Available
Granuloma23.03.15.001; 08.01.05.0010.009667%Not Available
Gynaecomastia21.05.04.003; 05.05.02.0030.045111%
Haematemesis24.07.02.011; 07.12.02.0020.006444%Not Available
Haematuria24.07.01.047; 20.02.01.0060.054778%
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.0030.032222%Not Available
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.0060.006444%Not Available
Haemorrhoids24.10.02.002; 07.15.03.0010.006444%
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