| Pharmaceutical Information |
| Drug Name |
Bepotastine besilate |
| Drug ID |
BADD_D00253 |
| Description |
Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor. Bepotastine was approved in Japan for use in the treatment of allergic rhinitis and uriticaria/puritus in July 2000 and January 2002, respectively, and is marketed by Tanabe Seiyaku Co., Ltd. under the brand name Talion. It is available in oral and opthalmic dosage forms in Japan. The opthalmic solution is FDA approved since Sept 8, 2009 and is under the brand name Bepreve. |
| Indications and Usage |
For the symptomatic treatment of itchy eyes (caused by IgE-induced mast cell degranulation) due to allergic conjunctivitis. |
| Marketing Status |
Prescription |
| ATC Code |
Not Available |
| DrugBank ID |
DB04890
|
| KEGG ID |
D01654
|
| MeSH ID |
C511534
|
| PubChem ID |
164521
|
| TTD Drug ID |
Not Available
|
| NDC Product Code |
40700-0040; 14501-0088; 24208-629; 0378-7055; 60505-6111; 16436-0106; 24208-630 |
| Synonyms |
bepotastine besilate |
|
| Chemical Information |
| Molecular Formula |
C27H31ClN2O6S |
| CAS Registry Number |
190786-44-8 |
| SMILES |
C1CN(CCC1OC(C2=CC=C(C=C2)Cl)C3=CC=CC=N3)CCCC(=O)O.C1=CC=C(C=C1)S(=O)(=O)O |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
| Dysgeusia | 07.14.03.001; 17.02.07.003 | - | - | | | Eye irritation | 06.04.05.003 | - | - | Not Available | | Headache | 17.14.01.001 | - | - | | | Lip swelling | 23.04.01.007; 10.01.05.005; 07.05.04.005 | - | - | Not Available | | Nasopharyngitis | 22.07.03.002; 11.01.13.002 | - | - | Not Available | | Pharyngeal oedema | 23.04.01.016; 22.04.05.003; 10.01.05.016 | - | - | Not Available | | Pruritus | 23.03.12.001 | - | - | | | Rash | 23.03.13.001 | - | - | Not Available | | Swollen tongue | 23.04.01.014; 10.01.05.015; 07.14.02.003 | - | - | Not Available |
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