| Drug Name |
Benztropine mesylate |
| Drug ID |
BADD_D00245 |
| Description |
Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970. The generation of structure-activity relationships proved that benztropine derivatives with the presence of a chlorine substituent in the para position in one of the phenyl rings produces an increased potency for dopamine uptake inhibition as well as a decreased inhibition of serotonin and norepinephrine.[A37914] Benztropine was developed by USL Pharma and officially approved by the FDA on 1996.[L5500] |
| Indications and Usage |
For use as an adjunct in the therapy of all forms of parkinsonism and also for use in the control of extrapyramidal disorders due to neuroleptic drugs. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
N04AC01 |
| DrugBank ID |
DB00245
|
| KEGG ID |
D00778
|
| MeSH ID |
D001590
|
| PubChem ID |
3246155
|
| TTD Drug ID |
D0HQ6N
|
| NDC Product Code |
76385-104; 76385-105; 62135-142; 63629-2132; 70518-2677; 64181-0088; 0832-1082; 0603-2434; 0904-6789; 0615-8210; 49452-1016; 70518-1688; 76339-138; 0615-8211; 70518-0881; 50090-3883; 30007-817; 0603-2433; 70518-1709; 0143-9233; 68475-512; 60687-379; 62135-144; 0603-2438; 63323-970; 70518-1691; 43353-707; 48954-448; 70518-1447; 58118-0043; 63629-2133; 60687-368; 0904-6790; 69315-137; 70518-0577; 63629-2135; 72166-005; 68382-860; 50090-4082; 63187-840; 70518-0720; 0143-9729; 43353-580; 50090-3882; 0603-2439; 69315-138; 0832-1080; 71610-502; 60687-356; 0904-6788; 0832-1081; 70518-2732; 0603-2437; 69315-136; 50090-3116; 63629-2134; 55154-8095; 0615-8352; 71335-0665; 76385-103; 61919-128; 0603-2435; 66064-1023 |
| Synonyms |
Benztropine | Benzatropine | Bensylate | Benzatropine Methanesulfonate | Methanesulfonate, Benzatropine | Benzatropine Mesylate | Mesylate, Benzatropine | Benztropine Mesylate | Mesylate, Benztropine | Benzatropine Methanesulfonate, Hydrobromide | Hydrobromide Benzatropine Methanesulfonate | Methanesulfonate, Hydrobromide Benzatropine | PMS-Benztropine | PMS Benztropine | Benzatropine Methanesulfonate, Hydrochloride, (endo)-Isomer | Cogentin | Cogentinol | N-Methylbenztropine | N Methylbenztropine | Apo-Benztropine | Apo Benztropine | Benzatropine Methanesulfonate, Hydrobromide, (endo)-Isomer |
