Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Benazepril hydrochloride
Drug ID BADD_D00228
Description Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure[A838,A837]. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor[A836].
Indications and Usage For the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.
Marketing Status Prescription; Discontinued
ATC Code C09AA07
DrugBank ID DB00542
KEGG ID D00620
MeSH ID C044946
PubChem ID 5362123
TTD Drug ID D0U3EC
NDC Product Code 71335-0854; 61919-756; 70934-228; 68071-5028; 68071-5087; 70518-3074; 61919-280; 50268-112; 71052-173; 68788-9327; 50268-109; 65862-118; 63187-906; 51927-0036; 43547-335; 71335-1365; 50090-5750; 68788-7845; 55154-4343; 68071-1769; 60760-352; 68071-4198; 50268-110; 51927-0105; 50268-111; 70518-3171; 68071-5088; 65162-751; 15308-0900; 65862-117; 42291-163; 50090-3359; 71335-0011; 68071-1026; 55700-291; 65862-346; 54458-862; 70518-1640; 51407-462; 51407-465; 30698-449; 68788-6889; 60760-351; 63629-8035; 70518-2125; 72189-110; 70518-0252; 71205-244; 43547-337; 50090-3243; 68071-3057; 54458-863; 68788-6957; 70518-3172; 68071-4722; 68071-5111; 63187-500; 43547-338; 70771-1150; 68071-5129; 65129-2021; 68788-9313; 70934-545; 30698-450; 71205-320; 51927-0104; 71335-0457; 65162-753; 30698-448; 42291-160; 65162-752; 65862-116; 43063-748; 22568-1136; 43063-677; 51407-464; 65162-754; 70771-1149; 58159-086; 70934-481; 70934-648; 68071-1969; 70771-1151; 70934-608; 71335-0267; 51407-463; 53002-1233; 70771-1148; 42291-161; 70934-483; 68071-5130; 63629-2679; 71335-0078; 50090-3775; 68071-4890; 64220-145; 63187-393; 50090-5751; 13612-0002; 50090-0913; 17404-0016; 43547-336; 68071-3142; 68071-3324; 43063-679; 68071-1146; 42291-162; 72969-005; 55154-4344; 63187-499; 71335-1299; 53002-1248
Synonyms benazepril | benazapril | benzazepril | Labopal | Lotensin | Cibacène | Cibacen | Briem | benazepril hydrochloride | CGS-14824-A | CGS-14824A
Chemical Information
Molecular Formula C24H29ClN2O5
CAS Registry Number 86541-74-4
SMILES CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Somnolence19.02.05.003; 17.02.04.006--
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Syncope02.01.02.008; 24.06.02.012; 17.02.04.008--
Tachycardia02.03.02.007--Not Available
Tension19.06.02.005--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tremor17.01.06.002--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary tract infection20.08.02.001; 11.01.14.004--
Ventricular extrasystoles02.03.04.007--Not Available
Vertigo17.02.12.002; 04.04.01.003--
Vomiting07.01.07.003--
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Protein urine present13.13.02.006--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Electrocardiogram change13.14.05.014--Not Available
Erectile dysfunction21.03.01.007; 19.08.04.001--
Lipoedema14.08.04.021--Not Available
Skin mass23.07.04.014--Not Available
Intestinal angioedema23.04.01.019; 10.01.05.019; 07.08.03.012--Not Available
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