Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Benazepril hydrochloride
Drug ID BADD_D00228
Description Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure[A838,A837]. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor[A836].
Indications and Usage For the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.
Marketing Status Prescription; Discontinued
ATC Code C09AA07
DrugBank ID DB00542
KEGG ID D00620
MeSH ID C044946
PubChem ID 5362123
TTD Drug ID D0U3EC
NDC Product Code 71335-0854; 61919-756; 70934-228; 68071-5028; 68071-5087; 70518-3074; 61919-280; 50268-112; 71052-173; 68788-9327; 50268-109; 65862-118; 63187-906; 51927-0036; 43547-335; 71335-1365; 50090-5750; 68788-7845; 55154-4343; 68071-1769; 60760-352; 68071-4198; 50268-110; 51927-0105; 50268-111; 70518-3171; 68071-5088; 65162-751; 15308-0900; 65862-117; 42291-163; 50090-3359; 71335-0011; 68071-1026; 55700-291; 65862-346; 54458-862; 70518-1640; 51407-462; 51407-465; 30698-449; 68788-6889; 60760-351; 63629-8035; 70518-2125; 72189-110; 70518-0252; 71205-244; 43547-337; 50090-3243; 68071-3057; 54458-863; 68788-6957; 70518-3172; 68071-4722; 68071-5111; 63187-500; 43547-338; 70771-1150; 68071-5129; 65129-2021; 68788-9313; 70934-545; 30698-450; 71205-320; 51927-0104; 71335-0457; 65162-753; 30698-448; 42291-160; 65162-752; 65862-116; 43063-748; 22568-1136; 43063-677; 51407-464; 65162-754; 70771-1149; 58159-086; 70934-481; 70934-648; 68071-1969; 70771-1151; 70934-608; 71335-0267; 51407-463; 53002-1233; 70771-1148; 42291-161; 70934-483; 68071-5130; 63629-2679; 71335-0078; 50090-3775; 68071-4890; 64220-145; 63187-393; 50090-5751; 13612-0002; 50090-0913; 17404-0016; 43547-336; 68071-3142; 68071-3324; 43063-679; 68071-1146; 42291-162; 72969-005; 55154-4344; 63187-499; 71335-1299; 53002-1248
Synonyms benazepril | benazapril | benzazepril | Labopal | Lotensin | Cibacène | Cibacen | Briem | benazepril hydrochloride | CGS-14824-A | CGS-14824A
Chemical Information
Molecular Formula C24H29ClN2O5
CAS Registry Number 86541-74-4
SMILES CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Loss of consciousness17.02.04.004--Not Available
Melaena24.07.02.013; 07.12.02.004--Not Available
Muscle spasms15.05.03.004--
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Neuritis17.09.03.001--Not Available
Neutropenia01.02.03.004--Not Available
Oedema08.01.07.006; 14.05.06.010--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oesophagitis07.08.05.001--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005--
Pemphigus23.03.01.005; 10.04.02.003--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photosensitivity reaction23.03.09.003--
Pollakiuria20.02.02.007--
Polyuria20.02.03.002--Not Available
Proteinuria20.02.01.011--
Pruritus23.03.12.001--
Pulmonary eosinophilia22.01.01.009; 01.02.04.006--Not Available
Rash23.03.13.001--Not Available
Respiratory disorder22.02.07.002--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Shock24.06.02.002--Not Available
Sinusitis22.07.03.007; 11.01.13.005--
The 3th Page    First    Pre   3 4    Next   Last    Total 4 Pages