Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Benazepril hydrochloride
Drug ID BADD_D00228
Description Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure[A838,A837]. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor[A836].
Indications and Usage For the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.
Marketing Status Prescription; Discontinued
ATC Code C09AA07
DrugBank ID DB00542
KEGG ID D00620
MeSH ID C044946
PubChem ID 5362123
TTD Drug ID D0U3EC
NDC Product Code 71335-0854; 61919-756; 70934-228; 68071-5028; 68071-5087; 70518-3074; 61919-280; 50268-112; 71052-173; 68788-9327; 50268-109; 65862-118; 63187-906; 51927-0036; 43547-335; 71335-1365; 50090-5750; 68788-7845; 55154-4343; 68071-1769; 60760-352; 68071-4198; 50268-110; 51927-0105; 50268-111; 70518-3171; 68071-5088; 65162-751; 15308-0900; 65862-117; 42291-163; 50090-3359; 71335-0011; 68071-1026; 55700-291; 65862-346; 54458-862; 70518-1640; 51407-462; 51407-465; 30698-449; 68788-6889; 60760-351; 63629-8035; 70518-2125; 72189-110; 70518-0252; 71205-244; 43547-337; 50090-3243; 68071-3057; 54458-863; 68788-6957; 70518-3172; 68071-4722; 68071-5111; 63187-500; 43547-338; 70771-1150; 68071-5129; 65129-2021; 68788-9313; 70934-545; 30698-450; 71205-320; 51927-0104; 71335-0457; 65162-753; 30698-448; 42291-160; 65162-752; 65862-116; 43063-748; 22568-1136; 43063-677; 51407-464; 65162-754; 70771-1149; 58159-086; 70934-481; 70934-648; 68071-1969; 70771-1151; 70934-608; 71335-0267; 51407-463; 53002-1233; 70771-1148; 42291-161; 70934-483; 68071-5130; 63629-2679; 71335-0078; 50090-3775; 68071-4890; 64220-145; 63187-393; 50090-5751; 13612-0002; 50090-0913; 17404-0016; 43547-336; 68071-3142; 68071-3324; 43063-679; 68071-1146; 42291-162; 72969-005; 55154-4344; 63187-499; 71335-1299; 53002-1248
Synonyms benazepril | benazapril | benzazepril | Labopal | Lotensin | Cibacène | Cibacen | Briem | benazepril hydrochloride | CGS-14824-A | CGS-14824A
Chemical Information
Molecular Formula C24H29ClN2O5
CAS Registry Number 86541-74-4
SMILES CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction10.01.07.003; 24.06.03.007--Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Back pain15.03.04.005--
Blood creatinine increased13.13.01.004--
Blood urea increased13.13.01.006--Not Available
Bronchitis11.01.09.001; 22.07.01.001--
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Constipation07.02.02.001--
Coordination abnormal17.02.02.004--Not Available
Cough22.02.03.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dizziness postural24.06.02.008; 17.02.05.004; 02.01.02.005--Not Available
Dry mouth07.06.01.002--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea02.01.03.002; 22.02.01.004--
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