Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Baclofen
Drug ID BADD_D00209
Description Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant used for the relief of painful and uncomfortable muscle spasms caused by a variety of conditions. It is particularly useful in treating muscle spasticity associated with spinal cord injury. This drug has recently been studied for the management of alcohol withdrawal, however, a conclusion has not been made regarding baclofen efficacy in this condition. [A173908,A173911,A173938] This drug was first approved by the FDA in 1992.[F4570]
Indications and Usage For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity.
Marketing Status Prescription; Discontinued
ATC Code M03BX01
DrugBank ID DB00181
KEGG ID D00241
MeSH ID D001418
PubChem ID 2284
TTD Drug ID D01AJY
NDC Product Code 0527-1333; 80425-0112; 67457-563; 70771-1449; 72888-011; 52817-321; 68071-2414; 68071-4905; 55700-408; 60687-514; 45865-355; 70518-0362; 68788-7915; 50090-5855; 63629-6883; 61919-095; 68071-5252; 80425-0157; 68981-007; 70518-2662; 70511-121; 51927-0146; 0527-1330; 48954-469; 70511-124; 76420-931; 55700-403; 50090-1801; 70710-1609; 67457-564; 52817-319; 46014-1124; 71610-444; 70518-2173; 68055-946; 63629-1228; 70756-085; 50090-4682; 71335-0949; 50268-107; 72888-009; 51927-0147; 12658-0584; 63629-2128; 12658-0583; 0115-1011; 63629-2081; 10135-533; 60687-503; 68788-9246; 68084-868; 59651-394; 63629-3193; 65015-635; 67457-562; 53747-075; 65628-100; 71335-1797; 25021-680; 68134-401; 0615-3542; 70710-1286; 63275-9992; 63629-2131; 76420-930; 70771-1586; 55154-7635; 12658-0582; 0832-1054; 17511-130; 73320-001; 70257-562; 70257-414; 72888-010; 25021-681; 81371-6004; 50090-0564; 63629-2129; 61919-093; 71930-066; 43063-865; 31722-138; 50090-1650; 63629-2080; 16714-072; 70518-3089; 0615-8411; 59651-395; 68788-6384; 71610-614; 31722-999; 80425-0156; 50436-9022; 0615-8412; 46014-1035; 38779-3209; 71610-452; 50268-106; 29300-344; 71335-0103; 55289-757; 73320-003; 10135-532; 51552-0613; 71610-446; 71335-1356; 70518-3115; 70511-122; 70710-1285; 71930-006; 70756-289; 63629-1225; 65628-101; 0904-6475; 79572-003; 16714-071; 71525-010; 70518-2804; 70511-123; 63629-1226; 71610-391; 63629-2130; 71335-1664; 63187-313; 71335-0206; 68084-855; 63629-2083; 29300-343; 42291-158; 0115-1010; 52652-6001; 73320-002; 50090-5838; 38779-0388; 63629-1227; 71930-007; 68071-2289; 0172-4096; 25021-678; 62991-1013; 17856-0319; 43063-864; 63629-2082; 63187-280; 71335-1643; 50090-2871; 0603-2406; 0527-1337; 12658-0448; 68055-947; 68055-945; 50436-0060; 63629-1224; 68055-948; 70934-918; 63629-6406; 51927-2007; 0615-3541; 70257-416; 50218-010; 68071-3001; 61919-027; 70934-227; 0904-6476; 45865-452; 63187-274; 51014-7035; 52817-320; 55154-7876; 80425-0080; 80425-0081; 0395-8032; 63629-1286; 63739-480; 71525-040; 71525-005; 61919-026; 76420-165; 63739-479; 0115-1012; 70257-412; 67544-671; 31722-998; 0832-1055; 70771-1448; 68071-2420; 50268-105; 70756-288; 68071-3075; 0172-4097; 0603-2407; 50090-2493; 71335-0344; 71205-474; 69528-301; 49452-0807; 68071-5249; 25021-679; 72969-004; 63187-147; 71335-1796; 63629-2084
Synonyms Baclofen | Baclophen | PCP-GABA | beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid | Chlorophenyl GABA | GABA, Chlorophenyl | beta-(p-Chlorophenyl)-gamma-aminobutyric Acid | Clofen | Gen-Baclofen | Gen Baclofen | GenBaclofen | Genpharm | Apo-Baclofen | Apo Baclofen | ApoBaclofen | Atrofen | Baclofène-Irex | Baclofène Irex | BaclofèneIrex | Baclofen AWD | AWD, Baclofen | Lebic | Lioresal | Liorésal | Nu-Baclo | Nu Baclo | NuBaclo | PMS-Baclofen | PMS Baclofen | PMSBaclofen | Baclospas | Ba-34,647 | Ba34,647 | Ba-34647 | Ba34647 | CIBA-34,647-BA | CIBA34,647BA
Chemical Information
Molecular Formula C10H12ClNO2
CAS Registry Number 1134-47-0
SMILES C1=CC(=CC=C1C(CC(=O)O)CN)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Drug ineffectiveAdenosine receptor A1P30542T920729655623; 9080460; 8880852
Parkinson's diseaseTumor necrosis factorP16599Not Available25547370
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haematoma24.07.01.001--
Haematuria24.07.01.047; 20.02.01.006--
Blood urine present13.13.02.002--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Hallucination19.10.02.0020.008755%
Hallucination, auditory19.10.02.0030.000842%Not Available
Hallucination, tactile19.10.02.0080.000337%Not Available
Hallucination, visual19.10.02.0040.002020%Not Available
Hallucinations, mixed19.10.02.0070.001010%Not Available
Headache17.14.01.001--
Heart rate decreased13.14.04.0010.001179%Not Available
Heart rate increased13.14.04.0020.002357%Not Available
Hemiparesis17.01.04.001--
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.001--Not Available
Hepatocellular injury09.01.07.0080.000842%Not Available
Hiatus hernia22.09.02.004; 07.16.01.0010.000673%Not Available
Hiccups22.02.04.002; 07.01.06.0090.000337%
Hypercapnia14.01.04.001; 22.02.02.0020.000842%Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.0280.007913%
Hyperkalaemia14.05.03.001--
Hyperkinesia17.01.02.0080.000337%Not Available
Hyperlactacidaemia14.01.01.0060.000337%Not Available
Hypernatraemia14.05.04.0010.000505%
Hyperreflexia17.02.01.0020.001347%Not Available
Hypersensitivity10.01.03.003--
Hypersomnia17.15.01.001; 19.02.05.0010.001179%
Hypertension24.08.02.0010.011617%
Hypertensive crisis24.08.01.001--Not Available
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