Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Baclofen
Drug ID BADD_D00209
Description Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant used for the relief of painful and uncomfortable muscle spasms caused by a variety of conditions. It is particularly useful in treating muscle spasticity associated with spinal cord injury. This drug has recently been studied for the management of alcohol withdrawal, however, a conclusion has not been made regarding baclofen efficacy in this condition. [A173908,A173911,A173938] This drug was first approved by the FDA in 1992.[F4570]
Indications and Usage For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity.
Marketing Status Prescription; Discontinued
ATC Code M03BX01
DrugBank ID DB00181
KEGG ID D00241
MeSH ID D001418
PubChem ID 2284
TTD Drug ID D01AJY
NDC Product Code 0527-1333; 80425-0112; 67457-563; 70771-1449; 72888-011; 52817-321; 68071-2414; 68071-4905; 55700-408; 60687-514; 45865-355; 70518-0362; 68788-7915; 50090-5855; 63629-6883; 61919-095; 68071-5252; 80425-0157; 68981-007; 70518-2662; 70511-121; 51927-0146; 0527-1330; 48954-469; 70511-124; 76420-931; 55700-403; 50090-1801; 70710-1609; 67457-564; 52817-319; 46014-1124; 71610-444; 70518-2173; 68055-946; 63629-1228; 70756-085; 50090-4682; 71335-0949; 50268-107; 72888-009; 51927-0147; 12658-0584; 63629-2128; 12658-0583; 0115-1011; 63629-2081; 10135-533; 60687-503; 68788-9246; 68084-868; 59651-394; 63629-3193; 65015-635; 67457-562; 53747-075; 65628-100; 71335-1797; 25021-680; 68134-401; 0615-3542; 70710-1286; 63275-9992; 63629-2131; 76420-930; 70771-1586; 55154-7635; 12658-0582; 0832-1054; 17511-130; 73320-001; 70257-562; 70257-414; 72888-010; 25021-681; 81371-6004; 50090-0564; 63629-2129; 61919-093; 71930-066; 43063-865; 31722-138; 50090-1650; 63629-2080; 16714-072; 70518-3089; 0615-8411; 59651-395; 68788-6384; 71610-614; 31722-999; 80425-0156; 50436-9022; 0615-8412; 46014-1035; 38779-3209; 71610-452; 50268-106; 29300-344; 71335-0103; 55289-757; 73320-003; 10135-532; 51552-0613; 71610-446; 71335-1356; 70518-3115; 70511-122; 70710-1285; 71930-006; 70756-289; 63629-1225; 65628-101; 0904-6475; 79572-003; 16714-071; 71525-010; 70518-2804; 70511-123; 63629-1226; 71610-391; 63629-2130; 71335-1664; 63187-313; 71335-0206; 68084-855; 63629-2083; 29300-343; 42291-158; 0115-1010; 52652-6001; 73320-002; 50090-5838; 38779-0388; 63629-1227; 71930-007; 68071-2289; 0172-4096; 25021-678; 62991-1013; 17856-0319; 43063-864; 63629-2082; 63187-280; 71335-1643; 50090-2871; 0603-2406; 0527-1337; 12658-0448; 68055-947; 68055-945; 50436-0060; 63629-1224; 68055-948; 70934-918; 63629-6406; 51927-2007; 0615-3541; 70257-416; 50218-010; 68071-3001; 61919-027; 70934-227; 0904-6476; 45865-452; 63187-274; 51014-7035; 52817-320; 55154-7876; 80425-0080; 80425-0081; 0395-8032; 63629-1286; 63739-480; 71525-040; 71525-005; 61919-026; 76420-165; 63739-479; 0115-1012; 70257-412; 67544-671; 31722-998; 0832-1055; 70771-1448; 68071-2420; 50268-105; 70756-288; 68071-3075; 0172-4097; 0603-2407; 50090-2493; 71335-0344; 71205-474; 69528-301; 49452-0807; 68071-5249; 25021-679; 72969-004; 63187-147; 71335-1796; 63629-2084
Synonyms Baclofen | Baclophen | PCP-GABA | beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid | Chlorophenyl GABA | GABA, Chlorophenyl | beta-(p-Chlorophenyl)-gamma-aminobutyric Acid | Clofen | Gen-Baclofen | Gen Baclofen | GenBaclofen | Genpharm | Apo-Baclofen | Apo Baclofen | ApoBaclofen | Atrofen | Baclofène-Irex | Baclofène Irex | BaclofèneIrex | Baclofen AWD | AWD, Baclofen | Lebic | Lioresal | Liorésal | Nu-Baclo | Nu Baclo | NuBaclo | PMS-Baclofen | PMS Baclofen | PMSBaclofen | Baclospas | Ba-34,647 | Ba34,647 | Ba-34647 | Ba34647 | CIBA-34,647-BA | CIBA34,647BA
Chemical Information
Molecular Formula C10H12ClNO2
CAS Registry Number 1134-47-0
SMILES C1=CC(=CC=C1C(CC(=O)O)CN)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Drug ineffectiveAdenosine receptor A1P30542T920729655623; 9080460; 8880852
Parkinson's diseaseTumor necrosis factorP16599Not Available25547370
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood glucose increased13.02.02.002--Not Available
Blood lactate dehydrogenase increased13.04.02.002--
Blood magnesium increased13.11.01.0090.000337%Not Available
Blood potassium decreased13.11.01.0100.001010%Not Available
Blood pressure decreased13.14.03.0020.002357%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood pressure systolic increased13.14.03.0060.000337%Not Available
Blood sodium decreased13.11.01.012--Not Available
Blood sodium increased13.11.01.0130.000673%Not Available
Blood urea increased13.13.01.0060.000842%Not Available
Body temperature decreased13.15.01.0100.000673%Not Available
Body temperature increased13.15.01.0010.000505%Not Available
Bradycardia02.03.02.0020.009934%Not Available
Bradypnoea22.02.01.0020.002020%Not Available
Breast cancer21.05.01.003; 16.10.01.001--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Burning sensation17.02.06.001; 08.01.09.029--Not Available
C-reactive protein increased13.09.01.0070.001347%Not Available
Cardiac arrest02.03.04.0010.002196%
Cardiac failure02.05.01.001--
Cardiac failure acute02.05.01.0050.000132%Not Available
Cardiac output decreased13.14.02.001--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.001010%Not Available
Cardiogenic shock02.05.01.003; 24.06.02.0060.000673%Not Available
Cardiomyopathy02.04.01.001--Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Catatonia19.11.01.0010.000505%Not Available
Cellulitis11.02.01.001; 23.09.01.001--Not Available
Cerebellar infarction24.04.06.007; 17.08.01.0130.000505%Not Available
Cerebral atrophy17.11.01.0010.000337%Not Available
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