Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Azathioprine
Drug ID BADD_D00195
Description Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
Indications and Usage Anstey A, Lear JT: Azathioprine: clinical pharmacology and current indications in autoimmune disorders. BioDrugs. 1998 Jan;9(1):33-47.
Marketing Status Prescription; Discontinued
ATC Code L04AX01
DrugBank ID DB00993
KEGG ID D00238
MeSH ID D001379
PubChem ID 2265
TTD Drug ID D07QCE
NDC Product Code 72789-129; 51407-182; 46014-1110; 62991-2189; 12780-0300; 51927-2258; 48954-909; 51552-0779; 15308-0732; 42973-143; 68382-120; 38779-0312; 68382-119; 67877-492; 70771-1139; 65649-241; 68382-118; 67877-494; 54766-590; 68462-502; 0378-1005; 71610-124; 60219-2036; 70771-1140; 51927-0071; 65841-602; 68382-003; 71610-306; 42291-071; 60219-2037; 68084-229; 60219-1076; 70771-1141; 49452-0783; 65649-231; 67877-495; 67877-493; 66122-0009
Synonyms Azathioprine | Azothioprine | Imurel | Imuran | Immuran | Azathioprine Sodium | Sodium, Azathioprine | Azathioprine Sodium Salt | Azathioprine Sulfate
Chemical Information
Molecular Formula C9H7N7O2S
CAS Registry Number 446-86-6
SMILES CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionThiopurine S-methyltransferaseP51580Not Available10461478; 12021625; 14566029; 8738760; 12021625
Adverse drug reactionThiopurine S-methyltransferaseP51580Not Available15228171; 9893619; 12525681; 7818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
Adverse drug reactionInosine triphosphate pyrophosphataseQ9BY32Not Available15167706; 15571265; 15973722
Bone marrow toxicityThiopurine S-methyltransferaseP51580Not Available15228171; 9893619; 12525681; 7818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
Bone marrow toxicityCytosolic 5'-nucleotidase 1AQ9BXI3Not Available7818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
Bone marrow toxicityPurine nucleoside phosphorylaseP00491T781987818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
Bone marrow toxicityThiopurine S-methyltransferaseP51580Not Available10461478; 12021625; 14566029; 8738760; 12021625
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Colon cancer recurrent16.13.01.013; 07.21.01.0110.001436%Not Available
Colonic fistula07.11.05.0070.002154%
Cutaneous leishmaniasis11.06.08.001; 23.09.05.0020.003590%Not Available
Diffuse large B-cell lymphoma stage IV16.28.02.004; 01.15.02.0040.000375%Not Available
Disseminated cryptococcosis11.03.04.0040.001436%Not Available
Endocarditis bacterial02.09.03.001; 11.02.01.0170.001436%Not Available
Ewing's sarcoma16.29.03.004; 15.09.03.0150.000375%Not Available
Eye infection toxoplasmal11.06.01.003; 06.04.05.0270.003590%Not Available
Guttate psoriasis23.03.14.0080.002154%Not Available
Hilar lymphadenopathy22.09.03.005; 01.09.01.0230.001436%Not Available
Histoplasmosis disseminated11.03.06.0030.007180%Not Available
IgA nephropathy20.05.01.016; 10.02.01.0630.002154%Not Available
Ileal stenosis07.13.06.0060.033028%
Intestinal fistula07.11.05.0120.009334%Not Available
Jejunal stenosis07.13.06.0070.002154%
Lymph node tuberculosis11.04.01.002; 01.09.01.0040.002872%Not Available
Lymphadenopathy mediastinal22.09.03.006; 01.09.01.0250.002872%Not Available
Malignant melanoma in situ23.08.01.004; 16.03.01.0040.001436%Not Available
Meningitis pneumococcal17.06.10.004; 11.02.06.0120.000562%Not Available
Metastases to lymph nodes16.22.02.006; 01.09.01.0150.000562%Not Available
Normal newborn18.08.06.0010.003590%Not Available
Purulent discharge11.01.08.061; 08.01.03.0760.001436%Not Available
Rectal stenosis07.13.05.0030.003590%
Small for dates baby18.04.02.0020.002154%Not Available
Splenic abscess11.01.18.009; 01.09.02.0110.000375%Not Available
Takayasu's arteritis10.02.02.028; 24.05.01.0080.002872%Not Available
Disseminated cytomegaloviral infection11.05.01.0160.000749%Not Available
Short-bowel syndrome12.02.03.024; 07.17.01.0100.004308%Not Available
Angiotensin converting enzyme increased13.04.02.0120.001436%Not Available
Live birth18.08.02.0070.002872%Not Available
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