ADReCS

Pharmaceutical Information

Drug Name	Azathioprine
Drug ID	BADD_D00195
Description	Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
Indications and Usage	Azathioprine is indicated to treat rheumatoid arthritis and prevent renal transplant rejection.[L11214]
Marketing Status	approved
ATC Code	L04AX01
DrugBank ID	DB00993
KEGG ID	D00238
MeSH ID	D001379
PubChem ID	2265
TTD Drug ID	D07QCE
NDC Product Code	62991-2189; 65649-231; 67877-492; 68084-229; 68382-120; 51407-182; 68382-118; 72789-129; 46014-1110; 70771-1141; 60219-1076; 60219-2036; 60219-2037; 68382-003; 48954-909; 51927-0071; 68682-241; 70518-3544; 70771-1140; 51927-2258; 54766-590; 65841-602; 12780-0300; 38779-0312; 66122-0009; 42291-063; 68462-502; 71610-124; 42291-071; 68682-231; 70771-1139; 15308-0732; 49452-0783; 67877-493; 51552-0779; 65649-241; 67877-494; 67877-495; 68382-119; 42973-143
UNII	MRK240IY2L
Synonyms	Azathioprine \| Azothioprine \| Imurel \| Imuran \| Immuran \| Azathioprine Sodium \| Sodium, Azathioprine \| Azathioprine Sodium Salt \| Azathioprine Sulfate

Chemical Information

Molecular Formula	C9H7N7O2S
CAS Registry Number	446-86-6
SMILES	CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Abnormal loss of weight	14.03.02.019	0.000783%		Not Available
Acute myelomonocytic leukaemia	16.01.05.005; 01.10.05.005	0.000627%		Not Available
Adenocarcinoma of colon	16.13.01.010; 07.21.01.008	0.000470%		Not Available
Alopecia areata	23.02.02.008; 10.04.02.011	0.000313%		Not Available
Behcet's syndrome	07.05.06.008; 06.04.05.017; 24.12.04.003; 23.06.02.004; 21.10.03.009; 15.01.01.009; 10.02.02.015	0.000627%		Not Available
Central nervous system lymphoma	16.20.01.005; 01.12.01.005; 18.04.04.013; 17.02.10.028	0.000783%		Not Available
Chloroma	01.10.08.003; 16.01.08.003	0.000313%		Not Available
Coeliac disease	14.02.01.007; 10.04.04.012; 07.17.01.008	0.000313%		Not Available
Colon cancer recurrent	16.13.01.013; 07.21.01.011	0.000313%		Not Available
Colonic fistula	07.11.05.007	0.000470%
Enthesopathy	15.07.01.011	-	-	Not Available
Ewing's sarcoma	16.29.03.004; 15.09.03.015	0.000313%		Not Available
Gastric mucosal hypertrophy	07.11.03.006	-	-	Not Available
Guttate psoriasis	23.03.14.008; 10.02.01.076	0.000470%		Not Available
Hilar lymphadenopathy	22.09.03.005; 01.09.01.023	0.000313%		Not Available
Ileal stenosis	07.13.06.006	0.007676%
Intestinal fistula	07.11.05.012	0.002037%		Not Available
Jejunal stenosis	07.13.06.007	0.000470%
Large for dates baby	18.04.02.004	0.000313%		Not Available
Lymphadenopathy mediastinal	22.09.03.006; 01.09.01.025	0.000783%		Not Available
Malignant melanoma in situ	23.08.01.004; 16.03.01.004	0.000313%		Not Available
Mesenteric vein thrombosis	07.15.02.013; 24.01.08.004	0.000313%		Not Available
Metastases to lymph nodes	16.22.02.006; 01.09.01.015	0.000470%		Not Available
Normal newborn	18.08.06.001	0.001692%		Not Available
Obstruction gastric	07.13.04.002	-	-
Rectal stenosis	07.13.05.003	0.000783%
Small for dates baby	18.04.02.002	0.000470%		Not Available
Takayasu's arteritis	24.12.02.008; 10.02.02.028	0.000783%		Not Available
Cholestasis of pregnancy	18.02.04.003; 09.01.01.013	0.004543%		Not Available
Short-bowel syndrome	12.02.03.024; 07.17.01.010	0.000940%		Not Available

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