Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Azathioprine
Drug ID BADD_D00195
Description Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
Indications and Usage Azathioprine is indicated to treat rheumatoid arthritis and prevent renal transplant rejection.[L11214]
Marketing Status approved
ATC Code L04AX01
DrugBank ID DB00993
KEGG ID D00238
MeSH ID D001379
PubChem ID 2265
TTD Drug ID D07QCE
NDC Product Code 62991-2189; 65649-231; 67877-492; 68084-229; 68382-120; 51407-182; 68382-118; 72789-129; 46014-1110; 70771-1141; 60219-1076; 60219-2036; 60219-2037; 68382-003; 48954-909; 51927-0071; 68682-241; 70518-3544; 70771-1140; 51927-2258; 54766-590; 65841-602; 12780-0300; 38779-0312; 66122-0009; 42291-063; 68462-502; 71610-124; 42291-071; 68682-231; 70771-1139; 15308-0732; 49452-0783; 67877-493; 51552-0779; 65649-241; 67877-494; 67877-495; 68382-119; 42973-143
UNII MRK240IY2L
Synonyms Azathioprine | Azothioprine | Imurel | Imuran | Immuran | Azathioprine Sodium | Sodium, Azathioprine | Azathioprine Sodium Salt | Azathioprine Sulfate
Chemical Information
Molecular Formula C9H7N7O2S
CAS Registry Number 446-86-6
SMILES CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pneumopericardium02.06.01.0070.000313%Not Available
Poor venous access24.03.02.017--Not Available
Hypoacusis04.02.01.006--
Seasonal allergy22.04.04.008; 10.01.04.001; 06.04.01.0130.000470%Not Available
Paradoxical drug reaction08.06.01.0140.000313%Not Available
Localised oedema14.05.06.009; 08.01.07.011; 02.05.04.0060.000627%
Weight fluctuation14.03.02.002--Not Available
Rectal discharge07.03.03.0050.000470%Not Available
Psychomotor skills impaired19.22.01.002; 17.02.10.0050.000313%Not Available
General physical health deterioration08.01.03.0180.002820%Not Available
Anal haemorrhage24.07.02.029; 07.12.03.004--
Muscle tightness15.05.03.0070.000313%Not Available
Pneumomediastinum22.09.03.0040.000313%Not Available
Anal inflammation07.03.03.0040.000313%
Dysstasia17.02.02.012; 15.03.05.011; 08.01.03.0890.000313%Not Available
Intervertebral disc protrusion15.10.01.0040.000470%Not Available
Subileus07.13.01.0040.001567%Not Available
Lupus-like syndrome23.03.02.004; 15.06.02.004; 10.04.03.0030.002350%Not Available
Fallopian tube cyst21.11.01.010; 16.04.01.004--Not Available
Musculoskeletal chest pain15.03.04.012; 22.09.01.001--
Nodular regenerative hyperplasia09.01.04.0040.004856%Not Available
Dyschezia07.02.03.005--Not Available
Facial paresis17.04.03.0020.000313%
Post transplant lymphoproliferative disorder16.21.02.004; 11.05.10.006; 01.13.02.0040.001723%Not Available
Systemic inflammatory response syndrome08.01.05.005; 24.06.03.008; 10.02.01.0080.001097%Not Available
Enterocutaneous fistula07.11.05.005; 23.07.04.0170.000783%Not Available
Large intestine polyp07.20.01.010; 16.05.02.0060.000783%Not Available
Ocular discomfort06.08.03.008--Not Available
Lymphatic disorder01.09.01.003--Not Available
Large intestinal haemorrhage24.07.02.026; 07.12.03.0030.000313%
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ADReCS-Target
Drug Name ADR Term Target
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