Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Azathioprine
Drug ID BADD_D00195
Description Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
Indications and Usage Anstey A, Lear JT: Azathioprine: clinical pharmacology and current indications in autoimmune disorders. BioDrugs. 1998 Jan;9(1):33-47.
Marketing Status Prescription; Discontinued
ATC Code L04AX01
DrugBank ID DB00993
KEGG ID D00238
MeSH ID D001379
PubChem ID 2265
TTD Drug ID D07QCE
NDC Product Code 72789-129; 51407-182; 46014-1110; 62991-2189; 12780-0300; 51927-2258; 48954-909; 51552-0779; 15308-0732; 42973-143; 68382-120; 38779-0312; 68382-119; 67877-492; 70771-1139; 65649-241; 68382-118; 67877-494; 54766-590; 68462-502; 0378-1005; 71610-124; 60219-2036; 70771-1140; 51927-0071; 65841-602; 68382-003; 71610-306; 42291-071; 60219-2037; 68084-229; 60219-1076; 70771-1141; 49452-0783; 65649-231; 67877-495; 67877-493; 66122-0009
Synonyms Azathioprine | Azothioprine | Imurel | Imuran | Immuran | Azathioprine Sodium | Sodium, Azathioprine | Azathioprine Sodium Salt | Azathioprine Sulfate
Chemical Information
Molecular Formula C9H7N7O2S
CAS Registry Number 446-86-6
SMILES CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionThiopurine S-methyltransferaseP51580Not Available15228171; 9893619; 12525681; 7818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
Adverse drug reactionInosine triphosphate pyrophosphataseQ9BY32Not Available15167706; 15571265; 15973722
Adverse drug reactionThiopurine S-methyltransferaseP51580Not Available10461478; 12021625; 14566029; 8738760; 12021625
Bone marrow toxicityThiopurine S-methyltransferaseP51580Not Available10461478; 12021625; 14566029; 8738760; 12021625
Bone marrow toxicityThiopurine S-methyltransferaseP51580Not Available15228171; 9893619; 12525681; 7818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
Bone marrow toxicityCytosolic 5'-nucleotidase 1AQ9BXI3Not Available7818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
Bone marrow toxicityPurine nucleoside phosphorylaseP00491T781987818564; 7979599; 9778228; 8984938; 12429535; 7774088; 12509611; 14505127
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ileal ulcer07.04.06.0080.005026%
Ileus07.13.01.0010.005026%
Immune system disorder10.02.01.0010.001436%Not Available
Incisional hernia12.02.05.017; 07.16.04.0010.001436%Not Available
Infection11.01.08.0020.004495%Not Available
Infectious mononucleosis11.05.10.003; 01.02.01.0070.004308%Not Available
Inflammatory bowel disease07.08.01.0160.005026%Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Influenza like illness08.01.03.0100.007898%
Inguinal hernia07.16.02.0010.001436%Not Available
Insomnia19.02.01.002; 17.15.03.002--
Interstitial lung disease22.01.02.003; 10.02.01.0330.001873%Not Available
Intestinal dilatation07.02.02.0100.002872%Not Available
Intestinal obstruction07.13.01.0020.034464%Not Available
Intestinal perforation07.04.06.0020.008616%Not Available
Intestinal stenosis07.13.01.0030.028720%Not Available
Intestinal ulcer07.04.06.0030.003590%Not Available
Iridocyclitis06.04.03.0010.003590%Not Available
Iron deficiency anaemia14.13.02.001; 01.03.01.0020.007180%Not Available
Irritable bowel syndrome19.24.01.003; 07.02.04.0030.002154%Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.005026%Not Available
Jaundice cholestatic09.01.01.0050.002154%Not Available
Joint stiffness15.01.02.0030.002872%Not Available
Joint swelling15.01.02.004--Not Available
Kaposi's sarcoma16.33.02.001; 11.05.17.0010.006462%Not Available
Laceration23.03.11.004; 12.01.06.0060.002154%Not Available
Large intestine perforation12.02.03.005; 07.04.06.0050.000749%
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.0030.002872%
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.007898%
Leukocytosis01.02.01.002--
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