ADReCS

Pharmaceutical Information

Drug Name	Azacitidine
Drug ID	BADD_D00194
Description	A pyrimidine nucleoside analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.
Indications and Usage	For treatment of patients with the following French-American-British myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation (now classified as acute myelogenous leukemia with multilineage dysplasia), and chronic myelomonocytic leukemia.
Marketing Status	approved; investigational
ATC Code	L01BC07
DrugBank ID	DB00928
KEGG ID	D03021
MeSH ID	D001374
PubChem ID	9444
TTD Drug ID	D09FAZ
NDC Product Code	0781-9253; 14096-121; 81955-0012; 16729-306; 55150-393; 63323-771; 68001-527; 69097-368; 69097-805; 71288-153; 72485-201; 65129-1222; 68554-0104; 72606-558; 53183-4011; 43598-678; 59572-102; 51916-350; 83137-0006; 16714-927; 43817-906; 59572-730; 68001-504; 71288-115; 63660-0010; 0781-3253; 42385-312; 66529-0013; 54893-0029; 82920-015; 68001-313; 42385-719; 43598-305; 16714-578; 51991-797; 64679-096; 70121-1237; 63592-1800; 0143-9606; 43598-143; 43598-465; 59572-740
UNII	M801H13NRU
Synonyms	Azacitidine \| 5-Azacytidine \| 5 Azacytidine \| Azacytidine \| Vidaza \| NSC-102816 \| NSC 102816 \| NSC102816

Chemical Information

Molecular Formula	C8H12N4O5
CAS Registry Number	320-67-2
SMILES	C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Hypoxia	22.02.02.003	0.001455%
Ileus	07.13.01.001	0.000280%
Immune system disorder	10.02.01.001	0.000280%		Not Available
Infection	11.01.08.002	-	-	Not Available
Inguinal hernia	07.16.02.001	0.000280%		Not Available
Injection site bruising	08.02.03.042; 24.07.06.017; 23.03.11.015; 12.07.03.042	0.000168%		Not Available
Injection site dermatitis	23.03.04.033; 12.07.03.041; 08.02.03.041	-	-	Not Available
Injection site erythema	23.03.06.015; 12.07.03.001; 08.02.03.001	0.000839%		Not Available
Injection site granuloma	12.07.03.003; 08.02.03.003; 23.03.15.003	-	-	Not Available
Injection site haematoma	24.07.01.009; 12.07.03.004; 08.02.03.004	0.000246%		Not Available
Injection site haemorrhage	24.07.01.010; 12.07.03.005; 08.02.03.005	0.000280%		Not Available
Injection site induration	08.02.03.007; 12.07.03.007	0.000112%		Not Available
Injection site infection	12.07.03.008; 11.01.08.005; 08.02.03.019	-	-	Not Available
Injection site inflammation	12.07.03.009; 08.02.03.008	0.000168%		Not Available
Injection site irritation	12.07.03.027; 08.02.03.027	0.000168%		Not Available
Injection site mass	12.07.03.010; 08.02.03.009	0.000302%		Not Available
Injection site necrosis	12.07.03.020; 08.02.03.020	0.000168%		Not Available
Injection site pain	12.07.03.011; 08.02.03.010	0.000940%		Not Available
Injection site pruritus	23.03.12.007; 12.07.03.014; 08.02.03.013	-	-	Not Available
Injection site rash	08.02.03.032; 23.03.13.010; 12.07.03.032	0.000112%		Not Available
Injection site reaction	12.07.03.015; 08.02.03.014	0.003313%
Injection site vesicles	12.07.03.051; 08.02.03.051; 23.03.01.024	0.000112%		Not Available
Insomnia	19.02.01.002; 17.15.03.002	-	-
Interstitial lung disease	22.01.02.003; 10.02.01.033	0.002574%		Not Available
Intestinal obstruction	07.13.01.002	0.000504%		Not Available
Intestinal ulcer	07.04.06.003	0.000112%		Not Available
Large intestine perforation	07.04.06.005; 12.02.03.005	0.000224%
Laryngeal pain	22.12.03.010	0.000168%
Left ventricular failure	02.05.02.001	0.000112%		Not Available
Lethargy	19.04.04.004; 17.02.04.003; 08.01.01.008	-	-

The 7th Page First Pre 7 8 9 10 11 Next Last Total 19 Pages