ADReCS

Pharmaceutical Information

Drug Name	Azacitidine
Drug ID	BADD_D00194
Description	A pyrimidine nucleoside analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.
Indications and Usage	For treatment of patients with the following French-American-British myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation (now classified as acute myelogenous leukemia with multilineage dysplasia), and chronic myelomonocytic leukemia.
Marketing Status	approved; investigational
ATC Code	L01BC07
DrugBank ID	DB00928
KEGG ID	D03021
MeSH ID	D001374
PubChem ID	9444
TTD Drug ID	D09FAZ
NDC Product Code	0781-9253; 14096-121; 81955-0012; 16729-306; 55150-393; 63323-771; 68001-527; 69097-368; 69097-805; 71288-153; 72485-201; 65129-1222; 68554-0104; 72606-558; 53183-4011; 43598-678; 59572-102; 51916-350; 83137-0006; 16714-927; 43817-906; 59572-730; 68001-504; 71288-115; 63660-0010; 0781-3253; 42385-312; 66529-0013; 54893-0029; 82920-015; 68001-313; 42385-719; 43598-305; 16714-578; 51991-797; 64679-096; 70121-1237; 63592-1800; 0143-9606; 43598-143; 43598-465; 59572-740
UNII	M801H13NRU
Synonyms	Azacitidine \| 5-Azacytidine \| 5 Azacytidine \| Azacytidine \| Vidaza \| NSC-102816 \| NSC 102816 \| NSC102816

Chemical Information

Molecular Formula	C8H12N4O5
CAS Registry Number	320-67-2
SMILES	C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Haemodynamic instability	24.03.02.006	0.000168%		Not Available
Gastrointestinal hypomotility	07.02.02.005	0.000112%		Not Available
Catheter site erythema	23.03.06.014; 12.07.02.003; 08.02.02.003	0.000246%		Not Available
Lymphatic disorder	01.09.01.003	-	-	Not Available
Large intestinal haemorrhage	24.07.02.026; 07.12.03.003	0.000168%
Drug tolerance decreased	08.06.01.024	0.000112%		Not Available
Perirectal abscess	11.01.07.005; 07.19.04.001	-	-	Not Available
Musculoskeletal discomfort	15.03.04.001	-	-	Not Available
Leukaemia cutis	16.01.03.002; 01.10.03.002	-	-	Not Available
Inappropriate antidiuretic hormone secretion	14.05.07.001; 05.03.03.001	0.000336%		Not Available
Febrile bone marrow aplasia	08.05.02.005; 01.03.03.007	0.000504%		Not Available
Injection site swelling	12.07.03.018; 08.02.03.017	-	-	Not Available
Cerebral haematoma	17.08.01.014; 24.07.04.006	0.000112%		Not Available
Nodule	08.03.05.002	-	-	Not Available
Klebsiella sepsis	11.02.03.002	-	-	Not Available
Haemorrhoidal haemorrhage	24.10.02.001; 07.15.03.002	-	-
Infusion site reaction	12.07.05.006; 08.02.05.005	-	-	Not Available
Haemorrhage	24.07.01.002	0.002742%		Not Available
Haemorrhage urinary tract	24.07.01.007; 20.02.03.005	0.000168%		Not Available
Faecaloma	07.01.03.004	0.000504%		Not Available
Pulmonary mass	22.02.07.004	0.000112%		Not Available
Intra-abdominal haematoma	24.07.02.034; 07.12.02.005	0.000112%		Not Available
Pneumatosis intestinalis	07.11.01.043	0.000280%		Not Available
Toxic skin eruption	10.01.01.008; 12.03.01.073; 23.03.05.003	0.000168%		Not Available
Staphylococcal infection	11.02.05.002	-	-	Not Available
Metabolic disorder	14.11.01.001	0.000168%		Not Available
Lung neoplasm malignant	22.08.01.001; 16.19.02.001	0.000504%		Not Available
Application site discolouration	23.03.03.023; 12.07.01.030; 08.02.01.030	0.000112%		Not Available
Gastrointestinal toxicity	12.03.01.019; 07.08.03.006	0.000694%		Not Available
Angiopathy	24.03.02.007	-	-	Not Available

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