Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Azacitidine
Drug ID BADD_D00194
Description A pyrimidine nucleoside analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.
Indications and Usage For treatment of patients with the following French-American-British myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation (now classified as acute myelogenous leukemia with multilineage dysplasia), and chronic myelomonocytic leukemia.
Marketing Status Prescription
ATC Code L01BC07
DrugBank ID DB00928
KEGG ID D03021
MeSH ID D001374
PubChem ID 9444
TTD Drug ID D09FAZ
NDC Product Code 43598-678; 59572-740; 16729-306; 71288-115; 16714-927; 0781-3253; 43598-305; 71288-153; 63592-1800; 68001-313; 63759-0015; 67457-254; 59572-730; 70121-1237; 68001-527; 72606-558; 69097-805; 69097-368; 0781-9253; 59572-102; 64679-096; 68554-0104; 66529-0013; 63660-0010; 14096-121; 51991-797; 42385-719; 63323-771; 51916-350; 68001-504; 65129-1222; 72485-201; 43598-465; 53183-4011; 0143-9606; 43817-906; 54893-0029
Synonyms Azacitidine | 5-Azacytidine | 5 Azacytidine | Azacytidine | Vidaza | NSC-102816 | NSC 102816 | NSC102816
Chemical Information
Molecular Formula C8H12N4O5
CAS Registry Number 320-67-2
SMILES C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Mouth ulceration07.05.06.004--Not Available
Mucormycosis22.07.03.021; 17.06.09.003; 11.03.05.011; 07.05.07.0110.000139%Not Available
Mucosal inflammation08.01.06.0020.002398%Not Available
Mucosal ulceration08.01.06.0030.000533%Not Available
Muscle haemorrhage24.07.01.037; 15.05.03.0170.000533%Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Myelodysplastic syndrome16.01.04.001; 01.10.04.0010.012579%
Myelofibrosis01.13.03.005; 16.21.03.0010.000834%Not Available
Myocardial infarction24.04.04.009; 02.02.02.007--
Myocardial ischaemia24.04.04.010; 02.02.02.0080.000347%Not Available
Myositis15.05.01.0010.001066%
Nasal congestion22.04.04.001--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neck pain15.03.04.009--
Necrotising fasciitis15.03.03.004; 11.01.17.0020.000486%Not Available
Neoplasm16.16.02.0010.000903%Not Available
Neoplasm malignant16.16.01.001--Not Available
Nephropathy20.05.03.0010.001066%Not Available
Nephropathy toxic20.05.03.002; 12.03.01.0100.000533%Not Available
Nervous system disorder17.02.10.0010.002398%Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.0040.039962%Not Available
Neutrophil count decreased13.01.06.0100.011722%
Night sweats08.01.03.031; 23.02.03.0060.001066%Not Available
Non-Hodgkin's lymphoma16.35.01.001; 01.17.01.0010.000208%Not Available
Obliterative bronchiolitis22.03.01.0120.000139%Not Available
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