Pharmaceutical Information |
Drug Name |
Axitinib |
Drug ID |
BADD_D00193 |
Description |
Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3).[L6676] Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times higher than that of the first generation VEGFR inhibitors.[L6676] Axitinib is an indazole derivative.[A179398] It is most commonly marketed under the name Inlyta® and is available in oral formulations. |
Indications and Usage |
Used in kidney cell cancer and investigated for use/treatment in pancreatic and thyroid cancer. |
Marketing Status |
Prescription |
ATC Code |
L01EK01 |
DrugBank ID |
DB06626
|
KEGG ID |
D03218
|
MeSH ID |
D000077784
|
PubChem ID |
6450551
|
TTD Drug ID |
D01ZRI
|
NDC Product Code |
54893-0043; 68554-0088; 54893-0032; 65344-0033; 63539-044; 0069-0151; 0069-0145; 63539-026 |
Synonyms |
Axitinib | AG 013736 | AG013736 | AG-013736 | Inlyta |
|
Chemical Information |
Molecular Formula |
C22H18N4OS |
CAS Registry Number |
319460-85-0 |
SMILES |
CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4 |
Chemical Structure |
|
|
ADR Related Proteins Induced by Drug |
ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
Not Available | Not Available | Not Available | Not Available | Not Available |
|
ADRs Induced by Drug |
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