Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Avanafil
Drug ID BADD_D00192
Description Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively lower risk of visual disturbances associated with off-target PDE6 inhibition.[L32113] It first received FDA approval on April 27, 2012,[L32058] with subsequent EMA approval in June 2013.[L32113]
Indications and Usage Treatment of erectile dysfunction in males.
Marketing Status Prescription
ATC Code G04BE10
DrugBank ID DB06237
KEGG ID D03217
MeSH ID C553414
PubChem ID 9869929
TTD Drug ID D0Y5JC
NDC Product Code 72384-751; 53360-1143; 53360-1142; 72384-752; 76299-322; 76299-320; 69037-0019; 72384-753; 76299-321; 53360-1141; 14501-0090
Synonyms avanafil | 4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)-1-pyrrolidinyl)-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide | stendra
Chemical Information
Molecular Formula C23H26ClN7O3
CAS Registry Number 330784-47-9
SMILES COC1=C(C=C(C=C1)CNC2=NC(=NC=C2C(=O)NCC3=NC=CC=N3)N4CCCC4CO)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Weight increased13.15.01.006--
Wheezing22.03.01.009--
Seasonal allergy22.04.04.008; 10.01.04.001; 06.04.01.013--Not Available
Spontaneous penile erection21.03.01.010--Not Available
Muscle tightness15.05.03.007--Not Available
Deep vein thrombosis24.01.02.003--Not Available
Upper respiratory tract congestion22.02.05.019--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Angiopathy24.03.02.007--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
Hot flush21.02.02.001; 08.01.03.027; 24.03.01.005--
Prostate cancer21.04.02.002; 16.25.01.001--Not Available
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Infestation23.09.05.001; 11.09.01.001--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Oropharyngeal pain22.02.05.022; 07.05.05.004--
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