Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Avanafil
Drug ID BADD_D00192
Description Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively lower risk of visual disturbances associated with off-target PDE6 inhibition.[L32113] It first received FDA approval on April 27, 2012,[L32058] with subsequent EMA approval in June 2013.[L32113]
Indications and Usage Treatment of erectile dysfunction in males.
Marketing Status Prescription
ATC Code G04BE10
DrugBank ID DB06237
KEGG ID D03217
MeSH ID C553414
PubChem ID 9869929
TTD Drug ID D0Y5JC
NDC Product Code 72384-751; 53360-1143; 53360-1142; 72384-752; 76299-322; 76299-320; 69037-0019; 72384-753; 76299-321; 53360-1141; 14501-0090
Synonyms avanafil | 4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)-1-pyrrolidinyl)-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide | stendra
Chemical Information
Molecular Formula C23H26ClN7O3
CAS Registry Number 330784-47-9
SMILES COC1=C(C=C(C=C1)CNC2=NC(=NC=C2C(=O)NCC3=NC=CC=N3)N4CCCC4CO)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nausea07.01.07.001--
Nephrolithiasis20.04.01.002--
Nervous system disorder17.02.10.001--Not Available
Oedema peripheral08.01.07.007; 02.05.04.007; 14.05.06.011--
Optic ischaemic neuropathy24.04.10.001; 17.04.05.006; 06.07.03.001--Not Available
Pain in extremity15.03.04.010--
Palpitations02.01.02.003--
Penile haemorrhage24.07.03.018; 21.12.01.011--Not Available
Penis disorder21.12.01.001--Not Available
Pollakiuria20.02.02.007--
Premature ejaculation21.03.01.008; 19.08.01.002--Not Available
Priapism21.03.01.005--Not Available
Prostatic specific antigen increased13.22.01.001--Not Available
Pruritus23.03.12.001--
Pruritus genital23.03.12.008; 21.10.01.002--Not Available
Rash23.03.13.001--Not Available
Rhinorrhoea22.02.05.010--
Sinus congestion22.04.06.001--Not Available
Sinus headache22.02.05.023; 17.14.01.002--
Sinusitis22.07.03.007; 11.01.13.005--
Skin disorder23.03.03.007--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Tachycardia02.03.02.007--Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
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