Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Avanafil
Drug ID BADD_D00192
Description Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively lower risk of visual disturbances associated with off-target PDE6 inhibition.[L32113] It first received FDA approval on April 27, 2012,[L32058] with subsequent EMA approval in June 2013.[L32113]
Indications and Usage Treatment of erectile dysfunction in males.
Marketing Status Prescription
ATC Code G04BE10
DrugBank ID DB06237
KEGG ID D03217
MeSH ID C553414
PubChem ID 9869929
TTD Drug ID D0Y5JC
NDC Product Code 72384-751; 53360-1143; 53360-1142; 72384-752; 76299-322; 76299-320; 69037-0019; 72384-753; 76299-321; 53360-1141; 14501-0090
Synonyms avanafil | 4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)-1-pyrrolidinyl)-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide | stendra
Chemical Information
Molecular Formula C23H26ClN7O3
CAS Registry Number 330784-47-9
SMILES COC1=C(C=C(C=C1)CNC2=NC(=NC=C2C(=O)NCC3=NC=CC=N3)N4CCCC4CO)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain lower07.01.05.010--Not Available
Adenoviral upper respiratory infection22.07.02.006; 11.05.09.002--Not Available
Agitation19.06.02.001; 17.02.05.012--
Alanine aminotransferase increased13.03.01.003--
Angina pectoris02.02.02.002; 24.04.04.002--
Angina unstable24.04.04.004; 02.02.02.004--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Balanoposthitis21.09.03.001--Not Available
Blood bilirubin increased13.03.01.008--
Blood creatinine increased13.13.01.004--
Blood glucose increased13.02.02.002--Not Available
Blood pressure increased13.14.03.005--Not Available
Body temperature increased13.15.01.001--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Cardiac murmur13.14.01.001--Not Available
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.002--Not Available
Chromatopsia06.02.05.001--Not Available
Constipation07.02.02.001--
Cough22.02.03.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dyspepsia07.01.02.001--
Dyspnoea exertional22.02.01.005; 02.01.03.003--Not Available
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