Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Atropine
Drug ID BADD_D00189
Description An alkaloid, originally from Atropa belladonna, but found in other plants, mainly solanaceae.
Indications and Usage For the treatment of poisoning by susceptible organophosphorous nerve agents having anti-cholinesterase activity (cholinesterase inhibitors) as well as organophosphorous or carbamate insecticides.
Marketing Status Prescription; Discontinued
ATC Code A03BA01; S01FA01
DrugBank ID DB00572
KEGG ID D00113
MeSH ID D001285
PubChem ID 174174
TTD Drug ID D0RG3O
NDC Product Code 69205-034; 60592-049; 11704-105; 63827-1015; 13371-488; 12714-034; 11704-106; 64181-0048; 11704-107; 11704-101; 11704-104
Synonyms Atropine | Atropinol | Atropine Sulfate | Sulfate, Atropine | Atropine Sulfate Anhydrous | Anhydrous, Atropine Sulfate | Sulfate Anhydrous, Atropine | AtroPen | Atropin Augenöl | Augenöl, Atropin
Chemical Information
Molecular Formula C17H23NO3
CAS Registry Number 51-55-8
SMILES CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Atrial fibrillationNot AvailableF1PE02Not Available25748673
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyponatraemia14.05.04.002--
Hypotension24.06.03.0020.001030%
Hypotonia15.05.04.008; 17.05.02.0020.000687%Not Available
Ileus paralytic07.02.05.001--Not Available
Impaired gastric emptying07.02.02.004--
Injection site reaction12.07.03.015; 08.02.03.014--
Insomnia19.02.01.002; 17.15.03.002--
Intraocular pressure increased13.07.04.0020.000687%Not Available
Irritability19.04.02.013; 08.01.03.011--
Keratitis06.04.02.002--
Labile blood pressure24.06.01.001--Not Available
Lacrimation decreased06.08.02.007--Not Available
Laryngitis22.07.03.001; 11.01.13.001--
Laryngospasm22.04.02.002--
Left ventricular failure02.05.02.001--Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukocytosis01.02.01.002--
Loss of consciousness17.02.04.004--Not Available
Loss of libido19.08.03.003--Not Available
Mania19.16.02.002--
Miosis17.02.11.002; 06.05.03.0030.000687%Not Available
Mucosal dryness08.01.06.0010.000687%Not Available
Muscle twitching15.05.03.005--Not Available
Mydriasis17.02.11.003; 06.05.03.0040.003777%Not Available
Myocardial infarction02.02.02.007; 24.04.04.009--
Myopia06.02.04.002--Not Available
Nasal congestion22.04.04.001--
Nasal dryness22.04.03.002--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
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