Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Armodafinil
Drug ID BADD_D00167
Description Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Indications and Usage Investigated for use/treatment in sleep disorders, obstructive sleep apnea, schizophrenia and schizoaffective disorders, depression, and bipolar disorders.
Marketing Status Prescription; Discontinued
ATC Code N06BA13
DrugBank ID DB06413
KEGG ID D03215
MeSH ID D000077408
PubChem ID 9690109
TTD Drug ID D0J5RN
NDC Product Code 65862-807; 71335-0681; 0093-3090; 0093-3092; 0093-3094; 63459-220; 0781-8029; 63285-827; 63459-215; 63629-7403; 65862-806; 65129-1185; 65015-784; 0781-8053; 63285-033; 71335-1193; 68788-7826; 65862-805; 55700-510; 63459-205; 11722-072; 71335-1308; 63285-032; 63459-225; 68180-572; 72189-041; 72189-133; 68788-7593; 0781-8037; 63285-030; 65862-998; 0378-3431; 68788-7880; 65862-795; 68180-569; 0378-3433; 71335-1842; 0378-3432; 72189-261; 59651-047; 71335-1857; 63629-7390; 0781-8045; 68180-573; 0093-3093; 48087-0066; 72789-060; 68180-571; 72789-126; 11722-055; 68788-7176; 71335-0710; 68788-7222
Synonyms Modafinil | 2-((Diphenylmethyl)sulfinyl)acetamide | Vigil | Sparlon | Nuvigil | Alertec | Benzhydrylsulfinylacetamide | Armodafinil | 2-((R)-(Diphenylmethyl)sulfinyl)acetamide | R-Modafinil | R Modafinil | Provigil | Modiodal | CRL 40476 | CRL-40476
Chemical Information
Molecular Formula C15H15NO2S
CAS Registry Number 112111-43-0
SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Psychiatric symptom19.01.02.001--Not Available
Drug intolerance08.06.01.0130.004562%Not Available
Psychotic disorder19.03.01.0020.003422%
Hypophagia07.01.06.010; 19.09.01.004; 14.03.01.0060.004562%Not Available
Treatment failure08.06.01.0170.000595%Not Available
Oropharyngeal pain22.02.05.022; 07.05.05.0040.003422%
Mouth swelling07.05.04.007; 23.04.01.020; 10.01.05.0200.002281%Not Available
Computerised tomogram abnormal13.18.03.0020.002281%Not Available
Pulmonary cavitation22.01.02.0220.002281%Not Available
Amphetamines positive13.17.02.0090.003422%Not Available
Vasogenic cerebral oedema17.07.02.0080.002281%Not Available
Intracranial mass17.11.01.0170.002281%Not Available
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