Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Armodafinil
Drug ID BADD_D00167
Description Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Indications and Usage Investigated for use/treatment in sleep disorders, obstructive sleep apnea, schizophrenia and schizoaffective disorders, depression, and bipolar disorders.
Marketing Status Prescription; Discontinued
ATC Code N06BA13
DrugBank ID DB06413
KEGG ID D03215
MeSH ID D000077408
PubChem ID 9690109
TTD Drug ID D0J5RN
NDC Product Code 65862-807; 71335-0681; 0093-3090; 0093-3092; 0093-3094; 63459-220; 0781-8029; 63285-827; 63459-215; 63629-7403; 65862-806; 65129-1185; 65015-784; 0781-8053; 63285-033; 71335-1193; 68788-7826; 65862-805; 55700-510; 63459-205; 11722-072; 71335-1308; 63285-032; 63459-225; 68180-572; 72189-041; 72189-133; 68788-7593; 0781-8037; 63285-030; 65862-998; 0378-3431; 68788-7880; 65862-795; 68180-569; 0378-3433; 71335-1842; 0378-3432; 72189-261; 59651-047; 71335-1857; 63629-7390; 0781-8045; 68180-573; 0093-3093; 48087-0066; 72789-060; 68180-571; 72789-126; 11722-055; 68788-7176; 71335-0710; 68788-7222
Synonyms Modafinil | 2-((Diphenylmethyl)sulfinyl)acetamide | Vigil | Sparlon | Nuvigil | Alertec | Benzhydrylsulfinylacetamide | Armodafinil | 2-((R)-(Diphenylmethyl)sulfinyl)acetamide | R-Modafinil | R Modafinil | Provigil | Modiodal | CRL 40476 | CRL-40476
Chemical Information
Molecular Formula C15H15NO2S
CAS Registry Number 112111-43-0
SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.0030.006844%Not Available
Oesophageal stenosis07.13.02.0010.002281%
Oral discomfort07.05.05.0010.002281%Not Available
Oral mucosal blistering07.05.05.0170.002281%Not Available
Pain08.01.08.004--
Palpitations02.01.02.0030.011406%
Pancytopenia01.03.03.003--Not Available
Panic attack19.06.04.0010.003422%Not Available
Paraesthesia17.02.06.0050.006844%
Personality change19.05.01.006; 17.02.05.0190.003422%
Pneumonia11.01.09.003; 22.07.01.003--Not Available
Polyuria20.02.03.002--Not Available
Productive cough22.02.03.0050.002281%
Pruritus23.03.12.0010.006844%
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.0010.052467%Not Available
Rash erythematous23.03.06.0030.002281%Not Available
Rash generalised23.03.13.0020.002281%Not Available
Seizure17.12.03.0010.009125%
Skin disorder23.03.03.007--Not Available
Skin exfoliation23.03.07.0030.002281%Not Available
Sleep apnoea syndrome22.02.01.013; 19.02.05.002; 17.15.05.0010.002281%
Somnolence17.02.04.006; 19.02.05.0030.025093%
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.0200.015968%
Stomatitis07.05.06.0050.009125%
Suicidal ideation19.12.01.0030.003422%
Swelling08.01.03.0150.003422%Not Available
Swollen tongue10.01.05.015; 07.14.02.003; 23.04.01.0140.010265%Not Available
The 4th Page    First    Pre   4 5 6    Next   Last    Total 6 Pages