Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Aripiprazole
Drug ID BADD_D00165
Description Aripiprazole is an atypical antipsychotic orally indicated for treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's[Label]. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania[Label]. Aripiprazole exerts its effects through agonism of dopaminic and 5-HT1A receptors and antagonism of alpha adrenergic and 5-HT2A receptors[Label,A4393]. Aripiprazole was given FDA approval on November 15, 2002[L6136].
Indications and Usage For the treatment of schizophrenia and related psychotic disorders.
Marketing Status Prescription; Discontinued
ATC Code N05AX12
DrugBank ID DB01238
KEGG ID D01164
MeSH ID D000068180
PubChem ID 60795
TTD Drug ID D0H3HM
NDC Product Code 48433-120; 59148-007; 68554-0095; 62332-099; 60505-2675; 59148-010; 76282-045; 68382-439; 27241-056; 71335-1903; 31722-829; 63629-7017; 46708-256; 16714-787; 60505-2674; 17856-0570; 59651-110; 43598-554; 70518-3380; 48433-115; 65862-662; 65862-680; 50090-4817; 65162-896; 33342-123; 70518-2565; 68788-7162; 13668-219; 76282-049; 71335-1980; 60429-451; 0904-6511; 0904-6656; 31722-820; 50370-0009; 48433-117; 16714-145; 50090-4160; 68554-0020; 55289-251; 70934-662; 59148-030; 43353-148; 46602-0045; 67877-432; 63629-7003; 46708-260; 68071-5062; 50370-0044; 70518-2508; 71335-1893; 42043-401; 27241-052; 50228-325; 68788-7733; 50090-4800; 46602-1031; 63739-413; 72865-185; 43547-304; 0904-6510; 43598-966; 59148-034; 70771-1454; 43547-303; 71335-0412; 27241-053; 60687-157; 29300-176; 43598-968; 76282-048; 43598-558; 59116-2901; 70771-1451; 46602-1029; 59148-018; 68382-083; 67877-433; 43547-306; 70518-1303; 50228-477; 69452-339; 68788-7808; 16729-279; 65162-902; 63415-0085; 70518-2765; 59148-011; 50228-324; 27241-054; 12828-0088; 70771-1456; 29300-178; 50090-5840; 67877-434; 43598-970; 50228-478; 62332-100; 50090-5839; 33342-126; 60505-2677; 46602-1032; 46602-0010; 31722-827; 72865-153; 72865-181; 53104-7628; 59148-045; 43598-967; 70518-2806; 46602-0006; 68788-7006; 46602-0026; 59148-029; 43598-555; 64220-112; 70518-2950; 33342-124; 50228-329; 70518-2584; 50090-4863; 16714-788; 60687-168; 70518-2869; 60505-2673; 13668-221; 43547-305; 43353-140; 72865-154; 16714-783; 72865-184; 33342-127; 62332-098; 71335-1935; 65862-666; 13668-216; 16729-280; 43353-180; 68382-085; 29300-179; 16714-141; 63629-6999; 65162-899; 65862-661; 43598-969; 0904-6514; 70518-2580; 16714-144; 70518-2567; 70518-2825; 70518-2736; 16714-146; 46602-0007; 66689-735; 58032-2005; 59148-072; 13668-217; 60429-446; 59148-032; 63187-965; 31722-830; 71335-1364; 65372-1121; 62332-097; 63739-070; 70518-2515; 16714-785; 50228-328; 70518-2536; 72865-183; 62332-101; 70518-2557; 0615-8375; 65862-663; 72865-182; 33342-122; 60505-2676; 43598-556; 71335-1682; 46602-0072; 50090-3941; 46602-0009; 43598-559; 46708-259; 68382-082; 50090-4936; 65691-0052; 43547-302; 46602-0008; 71205-480; 43598-965; 68382-084; 60429-449; 43547-307; 71335-1832; 71335-1515; 17856-0110; 50370-0055; 59148-006; 53747-031; 50228-327; 60505-3075; 50268-088; 70518-1263; 70518-2820; 13668-218; 50228-476; 72865-158; 50090-4665; 16729-278; 16714-786; 59148-008; 70518-2897; 72761-020; 68788-8089; 31722-819; 68788-7076; 65862-664; 70518-3011; 60687-213; 46602-0011; 72865-157; 29300-180; 76072-1002; 70518-2921; 46602-1030; 16729-282; 62332-102; 76282-047; 65841-140; 71335-1688; 70771-1455; 71335-1513; 46708-254; 48433-119; 60429-450; 65162-898; 60505-0404; 43353-147; 59148-031; 63739-074; 70771-1452; 46708-258; 0904-6509; 46708-255; 65162-897; 50268-091; 27241-051; 59148-019; 46602-1034; 76282-046; 46602-1033; 12658-0576; 0615-8259; 48433-118; 72865-155; 50228-480; 62332-103; 68788-7063; 0904-6512; 27241-055; 63629-7108; 50268-089; 53808-1101; 63739-078; 70518-3004; 68382-086; 70518-1421; 72865-180; 70518-2827; 50268-092; 16729-283; 66603-706; 68071-2394; 69452-338; 16729-281; 12658-0577; 70518-2514; 67877-431; 72865-156; 49706-1889; 68788-7749; 65862-665; 50268-087; 70518-2958; 69037-0058; 50228-475; 33342-125; 58623-0127; 63739-069; 70771-1453; 60429-447; 14445-019; 60429-448; 43598-557; 66603-705; 76282-044; 46602-0025; 50268-090; 71335-1687; 29300-177; 67835-0009; 31722-828; 71335-1892; 46708-261; 54838-570; 70518-0970; 60687-202; 71205-392; 63629-7774; 70518-3090; 67877-430; 16714-784; 29300-175; 70518-2974; 16714-143; 60687-179; 59148-033; 62332-104; 67877-435; 42043-400; 65096-0107; 13668-220; 16714-142; 46708-257; 50228-326; 48433-116; 65162-893; 59148-009; 50228-479; 0904-6513; 60687-191; 65162-901; 59116-2900; 71335-1711; 70518-2643
Synonyms Aripiprazole | 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone | Aripiprazol | Abilify | OPC 14597 | OPC-14597
Chemical Information
Molecular Formula C23H27Cl2N3O2
CAS Registry Number 129722-12-9
SMILES C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dermatitis exfoliative23.03.07.001; 10.01.01.0040.000381%
Diabetes insipidus14.05.07.003; 05.03.03.0040.000381%Not Available
Diabetes mellitus14.06.01.001; 05.06.01.0010.008963%Not Available
Diabetes mellitus inadequate control05.06.01.004; 14.06.01.0040.000572%Not Available
Diabetic coma17.02.09.004; 14.07.04.002; 05.07.04.0020.000381%Not Available
Diabetic hyperglycaemic coma17.02.09.006; 05.07.04.005; 14.07.04.0050.000100%Not Available
Diabetic hyperosmolar coma17.02.09.003; 14.07.04.001; 05.07.04.001--Not Available
Diabetic ketoacidosis14.07.03.001; 05.07.03.0010.005340%Not Available
Diarrhoea07.02.01.001--
Diastolic hypertension24.08.02.0060.000100%Not Available
Diet refusal14.03.01.011--Not Available
Diplopia17.17.01.005; 06.02.06.002--Not Available
Discomfort08.01.08.003--Not Available
Disorientation19.13.01.002; 17.02.05.0150.002479%Not Available
Disseminated intravascular coagulation24.01.01.010; 01.01.02.0020.000249%
Dissociation19.14.01.0020.000381%Not Available
Disturbance in attention19.21.02.002; 17.03.03.0010.004386%
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Dizziness exertional24.06.02.018; 17.02.05.034; 02.01.02.013--Not Available
Dizziness postural24.06.02.008; 17.02.05.004; 02.01.02.0050.000381%Not Available
Drooling17.02.05.0050.002670%Not Available
Drug abuse19.07.02.0100.002388%Not Available
Drug dependence19.07.02.009--Not Available
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.015--Not Available
Drug hypersensitivity10.01.01.001--Not Available
Drug withdrawal syndrome19.07.02.011; 08.06.02.004--Not Available
Drug withdrawal syndrome neonatal19.07.02.012; 18.04.13.001; 08.06.02.008--Not Available
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
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