Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apremilast
Drug ID BADD_D00156
Description Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene.[L7501] In July 2019, apremilast was granted a new FDA approval for the treatment of oral ulcers associated with Behcet's disease, an autoimmune condition that causes recurrent skin, blood vessel, and central nervous system inflammation.[A181216]
Indications and Usage Investigated for use/treatment in psoriasis and psoriatic disorders.
Marketing Status Prescription
ATC Code L04AA32
DrugBank ID DB05676
KEGG ID D08860
MeSH ID C505730
PubChem ID 10151715
TTD Drug ID D07ESC
NDC Product Code 65977-0119; 60219-1410; 60219-1744; 66406-0240; 66039-934; 70518-3155; 12658-0581; 69766-024; 59572-630; 65372-1204; 59572-631; 55513-369; 58032-2030; 59572-632; 53747-077; 55513-137; 59651-150; 53069-1040; 69766-010; 55513-485; 47621-306; 11722-062; 66406-0241; 46708-902; 65129-1383; 55111-993; 53069-1050; 73309-043; 49187-0757; 66406-0242
Synonyms apremilast | Otezla | CC 10004 | CC10004 | CC-10004
Chemical Information
Molecular Formula C22H24N2O7S
CAS Registry Number 253168-86-4
SMILES CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Conjunctivitis06.04.01.002; 11.01.06.012--
Constipation07.02.02.001--
Coronary artery disease02.02.01.001; 24.04.04.006--Not Available
Coronary artery occlusion02.02.01.006; 24.04.04.013--Not Available
Cough22.02.03.0010.259388%
Creatinine renal clearance decreased13.13.01.013--Not Available
Crohn's disease10.02.01.005; 07.08.01.015--Not Available
Crying17.02.05.013; 12.02.11.001; 08.01.03.005; 19.04.02.002--Not Available
Cyst16.02.02.002; 08.03.05.0010.009264%Not Available
Cystitis20.03.02.002; 11.01.14.0010.024318%
Cytomegalovirus hepatitis11.05.01.009; 09.01.09.0090.001158%Not Available
Dandruff23.03.16.0010.004632%Not Available
Deafness04.02.01.001--Not Available
Death08.04.01.001--
Decreased activity19.11.01.002; 08.01.01.006--Not Available
Decreased immune responsiveness10.02.01.041--Not Available
Decreased interest19.15.02.0040.009843%Not Available
Defaecation urgency07.02.04.0010.019686%Not Available
Dehydration14.05.05.001--
Delusion19.10.01.001--
Dementia17.03.01.001; 19.20.02.001--Not Available
Dementia Alzheimer's type19.20.03.001; 17.03.06.001--Not Available
Dental caries07.09.01.001--
Depressed level of consciousness17.02.04.002--
Depressed mood19.15.02.0010.075848%Not Available
Depression19.15.01.0010.950125%
Depression suicidal19.15.01.0040.010422%Not Available
Dermal cyst23.10.02.001; 16.26.02.0010.001737%Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis acneiform23.02.01.004--
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