Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apremilast
Drug ID BADD_D00156
Description Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene.[L7501] In July 2019, apremilast was granted a new FDA approval for the treatment of oral ulcers associated with Behcet's disease, an autoimmune condition that causes recurrent skin, blood vessel, and central nervous system inflammation.[A181216]
Indications and Usage Investigated for use/treatment in psoriasis and psoriatic disorders.
Marketing Status Prescription
ATC Code L04AA32
DrugBank ID DB05676
KEGG ID D08860
MeSH ID C505730
PubChem ID 10151715
TTD Drug ID D07ESC
NDC Product Code 65977-0119; 60219-1410; 60219-1744; 66406-0240; 66039-934; 70518-3155; 12658-0581; 69766-024; 59572-630; 65372-1204; 59572-631; 55513-369; 58032-2030; 59572-632; 53747-077; 55513-137; 59651-150; 53069-1040; 69766-010; 55513-485; 47621-306; 11722-062; 66406-0241; 46708-902; 65129-1383; 55111-993; 53069-1050; 73309-043; 49187-0757; 66406-0242
Synonyms apremilast | Otezla | CC 10004 | CC10004 | CC-10004
Chemical Information
Molecular Formula C22H24N2O7S
CAS Registry Number 253168-86-4
SMILES CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Appendix disorder07.11.01.0200.001737%Not Available
Arterial stenosis24.04.02.0120.001158%Not Available
Escherichia infection11.02.10.004--Not Available
Foot deformity15.10.03.005--Not Available
Papilloma viral infection11.05.07.0050.001737%Not Available
Grip strength decreased13.15.01.041--Not Available
Onychalgia23.02.05.0260.001737%Not Available
Nail growth abnormal23.02.05.0240.001737%Not Available
Tachyphrenia17.03.03.007; 19.10.03.010--Not Available
Ligament rupture15.07.02.008; 12.01.07.0140.003474%Not Available
Enlarged uvula07.05.01.0150.001158%Not Available
Stomach mass07.11.01.0300.001158%Not Available
Quality of life decreased13.18.01.013--Not Available
Skin plaque23.03.03.0440.010422%Not Available
Gastroenteritis norovirus11.05.22.001; 07.19.03.0170.001158%Not Available
C-reactive protein abnormal13.09.01.0230.001158%Not Available
Nail injury23.02.05.025; 12.01.06.0140.001737%Not Available
Rebound psoriasis23.03.14.010; 08.06.02.0190.010422%Not Available
Inflammatory marker increased13.09.02.0030.002316%Not Available
Mycobacterium tuberculosis complex test positive13.08.05.0040.011001%Not Available
Subchorionic haemorrhage18.02.01.007; 24.07.03.0300.001158%Not Available
Soft tissue mass15.03.02.0190.001158%Not Available
Spinal pain17.10.01.020; 15.02.01.008; 08.01.08.030--Not Available
Skin wound23.03.11.022; 12.01.06.0150.001158%Not Available
Sensitivity to weather change08.01.03.077--Not Available
Meniscus injury15.07.03.006; 12.04.03.0080.005790%Not Available
Tendon discomfort15.07.01.0120.001158%Not Available
Eyelid rash23.03.13.020; 06.04.04.0170.001158%Not Available
Chronic throat clearing22.02.05.0380.001158%Not Available
Root canal infection12.02.03.023; 11.01.04.019; 07.09.01.0080.001158%Not Available
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