Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apremilast
Drug ID BADD_D00156
Description Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene.[L7501] In July 2019, apremilast was granted a new FDA approval for the treatment of oral ulcers associated with Behcet's disease, an autoimmune condition that causes recurrent skin, blood vessel, and central nervous system inflammation.[A181216]
Indications and Usage Investigated for use/treatment in psoriasis and psoriatic disorders.
Marketing Status Prescription
ATC Code L04AA32
DrugBank ID DB05676
KEGG ID D08860
MeSH ID C505730
PubChem ID 10151715
TTD Drug ID D07ESC
NDC Product Code 65977-0119; 60219-1410; 60219-1744; 66406-0240; 66039-934; 70518-3155; 12658-0581; 69766-024; 59572-630; 65372-1204; 59572-631; 55513-369; 58032-2030; 59572-632; 53747-077; 55513-137; 59651-150; 53069-1040; 69766-010; 55513-485; 47621-306; 11722-062; 66406-0241; 46708-902; 65129-1383; 55111-993; 53069-1050; 73309-043; 49187-0757; 66406-0242
Synonyms apremilast | Otezla | CC 10004 | CC10004 | CC-10004
Chemical Information
Molecular Formula C22H24N2O7S
CAS Registry Number 253168-86-4
SMILES CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pityriasis rosea23.03.08.0030.001158%Not Available
Pneumonia influenzal22.07.05.008; 11.05.03.0030.001158%Not Available
Post inflammatory pigmentation change23.05.03.0020.001158%Not Available
Prostate cancer recurrent21.04.02.008; 16.25.01.0050.001158%Not Available
Recurrent cancer16.16.01.015--Not Available
Seasonal affective disorder19.04.04.0070.001158%Not Available
Spinal column stenosis17.10.01.011; 15.10.04.003--Not Available
Stasis dermatitis24.10.04.004; 23.03.04.0410.001158%Not Available
Sternal fracture15.08.07.002; 12.04.07.0020.001158%Not Available
Teeth brittle07.09.05.0150.001158%Not Available
Throat cancer22.08.02.008; 16.19.02.0070.002895%Not Available
Tibia fracture15.08.03.016; 12.04.01.016--Not Available
Violence-related symptom19.05.01.022--Not Available
Lower extremity mass15.03.01.0150.002316%Not Available
Weight loss poor14.03.02.0270.001158%Not Available
Neck mass15.03.02.007--Not Available
Lumbar vertebral fracture15.08.05.007; 12.04.04.007--Not Available
Transient acantholytic dermatosis23.03.03.0690.001158%Not Available
Full blood count increased13.01.07.002--Not Available
Corona virus infection11.05.04.0260.001158%Not Available
Joint warmth15.01.02.0090.001737%Not Available
Clostridium difficile infection11.02.02.009--Not Available
Breast cancer metastatic21.05.01.016; 16.10.01.008--Not Available
Colon cancer metastatic16.13.01.012; 07.21.01.010--Not Available
Gastric infection11.01.07.008; 07.19.03.003--Not Available
Hepatic mass09.01.08.0150.001158%Not Available
Periorbital cellulitis11.02.01.045; 06.04.11.0040.001158%Not Available
Negative thoughts19.15.02.0120.007527%Not Available
General physical condition abnormal13.15.01.040--Not Available
Sputum retention22.02.03.0120.001158%Not Available
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