Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apremilast
Drug ID BADD_D00156
Description Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene.[L7501] In July 2019, apremilast was granted a new FDA approval for the treatment of oral ulcers associated with Behcet's disease, an autoimmune condition that causes recurrent skin, blood vessel, and central nervous system inflammation.[A181216]
Indications and Usage Investigated for use/treatment in psoriasis and psoriatic disorders.
Marketing Status Prescription
ATC Code L04AA32
DrugBank ID DB05676
KEGG ID D08860
MeSH ID C505730
PubChem ID 10151715
TTD Drug ID D07ESC
NDC Product Code 65977-0119; 60219-1410; 60219-1744; 66406-0240; 66039-934; 70518-3155; 12658-0581; 69766-024; 59572-630; 65372-1204; 59572-631; 55513-369; 58032-2030; 59572-632; 53747-077; 55513-137; 59651-150; 53069-1040; 69766-010; 55513-485; 47621-306; 11722-062; 66406-0241; 46708-902; 65129-1383; 55111-993; 53069-1050; 73309-043; 49187-0757; 66406-0242
Synonyms apremilast | Otezla | CC 10004 | CC10004 | CC-10004
Chemical Information
Molecular Formula C22H24N2O7S
CAS Registry Number 253168-86-4
SMILES CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hand fracture15.08.03.014; 12.04.01.0140.004632%Not Available
Hangover08.01.09.0180.002316%Not Available
Head discomfort17.02.05.0270.012738%Not Available
Headache17.14.01.0013.552113%
Heart rate abnormal13.14.04.006--Not Available
Heart rate decreased13.14.04.001--Not Available
Heart rate increased13.14.04.002--Not Available
Heart rate irregular13.14.04.003--Not Available
Hepatic cirrhosis09.01.04.001--Not Available
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.001--Not Available
Hepatic steatosis14.08.04.005; 09.01.07.003--Not Available
Hepatitis09.01.07.004--Not Available
Hepatitis acute09.01.07.005--Not Available
Hepatitis B11.05.06.002; 09.01.09.003--
Hepatitis C11.05.06.004; 09.01.09.005--Not Available
Hereditary angioedema23.04.01.015; 10.01.05.012; 03.02.01.008--Not Available
Hernia08.01.04.0010.012159%Not Available
Herpes simplex23.09.03.001; 11.05.02.001--Not Available
Herpes virus infection11.05.02.0080.004053%Not Available
Herpes zoster23.09.03.002; 11.05.02.003--
Hiatus hernia22.09.02.004; 07.16.01.001--Not Available
Hiccups22.02.04.002; 07.01.06.009--
Hidradenitis23.02.03.0130.002316%Not Available
High density lipoprotein increased13.12.01.004--Not Available
Hip fracture15.08.03.001; 12.04.01.001--
HIV infection11.05.17.002; 10.03.03.0020.001737%Not Available
Hodgkin's disease16.31.01.001; 01.16.01.0010.000604%Not Available
Hordeolum11.01.06.002; 06.04.04.0060.004053%Not Available
Humerus fracture15.08.03.008; 12.04.01.009--Not Available
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