Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Apraclonidine
Drug ID BADD_D00154
Description Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.
Indications and Usage For prevention or reduction of intraoperative and postoperative increases in intraocular pressure (IOP) before and after ocular laser surgery when used prophylactically. Also used as a short-term adjunctive therapy in patients with open-angle glaucoma who are on maximally tolerated medical therapy requiring additional IOP reduction.
Marketing Status approved
ATC Code S01EA03
DrugBank ID DB00964
KEGG ID D07461
MeSH ID C016986
PubChem ID 2216
TTD Drug ID D0MT0M
NDC Product Code 61314-665
UNII 843CEN85DI
Synonyms apraclonidine | 4-aminoclonidine | para-aminoclonidine | 2-(4-amino-2,6-dichloro)phenyliminoimidazolidine | p-aminoclonidine | apraclonidine hydrochloride | Iopidine | Iopimax | ALO 2145 | ALO-2145
Chemical Information
Molecular Formula C9H10Cl2N4
CAS Registry Number 66711-21-5
SMILES C1CN=C(N1)NC2=C(C=C(C=C2Cl)N)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Pain08.01.08.004--
Pallor08.01.03.032; 24.03.04.001; 23.03.03.031--Not Available
Palpitations02.11.04.012--
Paraesthesia23.03.03.094; 17.02.06.005--
Parosmia22.04.03.007; 17.04.04.002--Not Available
Pharyngitis07.05.07.004; 22.07.03.004; 11.01.13.003--
Photophobia17.17.02.006; 06.01.01.004--
Presyncope02.11.04.013; 24.06.02.010; 17.02.05.009--
Pruritus23.03.12.001--
Rhinitis11.01.13.004; 22.07.03.006--
Rhinorrhoea22.12.03.021--
Scab23.03.03.004--Not Available
Skin disorder23.03.03.007--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Syncope17.02.04.008; 02.11.04.015; 24.06.02.012--
Tension19.06.02.005--Not Available
Throat irritation22.12.03.029; 07.05.05.037--Not Available
Vision blurred17.17.01.010; 06.02.06.007--
Visual acuity reduced06.02.10.012; 17.17.01.011--
Visual impairment06.02.10.013--Not Available
Vital dye staining cornea present13.07.04.010--Not Available
Vomiting07.01.07.003--
Foreign body sensation in eyes06.01.01.006--Not Available
Eyelid margin crusting23.03.03.029; 06.04.04.005--Not Available
Eye oedema06.08.03.013--Not Available
Eye pruritus06.04.05.006--Not Available
Ocular discomfort06.08.03.008--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
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