Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apomorphine hydrochloride
Drug ID BADD_D00153
Description Apomorphine is a non-ergoline dopamine D2 agonist indicated to treat hypomobility associated with Parkinson's. It was first synthesized in 1845 and first used in Parkinson's disease in 1884.[A203618] Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of other movement disorders.[A203597,A203618] Apomorphine was granted FDA approval on 20 April 2004.[L13919]
Indications and Usage For the acute, intermittent treatment of hypomobility, off episodes (end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson's disease.
Marketing Status Prescription; Discontinued
ATC Code G04BE07; N04BC07
DrugBank ID DB00714
KEGG ID D02004
MeSH ID D001058
PubChem ID 9410
TTD Drug ID D0H6QU
NDC Product Code 63402-015; 63402-120; 63402-115; 63402-010; 63402-188; 63402-020; 63402-130; 49452-0700; 38779-1764; 52817-720; 63402-125; 63402-088; 27505-004; 62991-1513; 52465-104; 52465-105; 63402-030; 63402-025; 12707-031; 51927-2303; 50396-6009; 63402-110
Synonyms Apomorphine | Apomorphine Hydrochloride, Anhydrous | Apomorphine Hydrochloride Anhydrous | Apomorphine Hydrochloride | Apomorphin-Teclapharm | Apomorphin Teclapharm | Apomorphine Hydrochloride, Hemihydrate | Apokinon | Apomorphine Chloride | Britaject
Chemical Information
Molecular Formula C17H18ClNO2
CAS Registry Number 314-19-2
SMILES CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionProtein c-FosP01100T28025Not Available
Tremor (excl congenital)Fatty acid-binding protein, adipocyteQ9R290Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rhinorrhoea22.02.05.010--
Somnolence19.02.05.003; 17.02.04.006--
Urinary tract infection20.08.02.001; 11.01.14.004--
Vomiting07.01.07.003--
Yawning22.02.05.017--Not Available
Peripheral swelling08.01.03.053; 02.05.04.015--Not Available
Impulse-control disorder19.18.01.002--Not Available
Parkinson's disease17.01.05.010--Not Available
Hypersexuality19.08.03.005--Not Available
Adverse reaction08.06.01.018--Not Available
Gambling disorder19.07.02.014--Not Available
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