Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apomorphine
Drug ID BADD_D00152
Description Apomorphine is a non-ergoline dopamine D2 agonist indicated to treat hypomobility associated with Parkinson's. It was first synthesized in 1845 and first used in Parkinson's disease in 1884.[A203618] Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of other movement disorders.[A203597,A203618] Apomorphine was granted FDA approval on 20 April 2004.[L13919]
Indications and Usage For the acute, intermittent treatment of hypomobility, off episodes (end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson's disease.
Marketing Status Prescription; Discontinued
ATC Code G04BE07; N04BC07
DrugBank ID DB00714
KEGG ID D07460
MeSH ID D001058
PubChem ID 6005
TTD Drug ID D0H6QU
NDC Product Code Not Available
Synonyms Apomorphine | Apomorphine Hydrochloride, Anhydrous | Apomorphine Hydrochloride Anhydrous | Apomorphine Hydrochloride | Apomorphin-Teclapharm | Apomorphin Teclapharm | Apomorphine Hydrochloride, Hemihydrate | Apokinon | Apomorphine Chloride | Britaject
Chemical Information
Molecular Formula C17H17NO2
CAS Registry Number 58-00-4
SMILES CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionProtein c-FosP01100T2802511070194; 1347413; 7477877
Tremor (excl congenital)Fatty acid-binding protein, adipocyteQ9R290Not Available25933950
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Insomnia19.02.01.002; 17.15.03.002--
Intestinal obstruction07.13.01.0020.001273%Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.000849%Not Available
Libido increased19.08.03.002; 21.03.02.007--
Loss of consciousness17.02.04.0040.002122%Not Available
Malaise08.01.01.0030.002122%
Mania19.16.02.0020.001698%
Muscle rigidity17.05.02.005; 15.05.04.0010.000849%Not Available
Muscle spasms15.05.03.0040.001273%
Myocardial infarction24.04.04.009; 02.02.02.007--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.0010.008489%
Oedema14.05.06.010; 08.01.07.006--Not Available
Orthostatic hypotension17.05.01.020; 24.06.03.004--Not Available
Pain in extremity15.03.04.0100.001698%
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Panniculitis23.07.02.002; 10.01.03.0240.002547%Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Priapism21.03.01.005--Not Available
Pruritus23.03.12.001--
Pyrexia08.05.02.0030.002122%
Rash23.03.13.001--Not Available
Respiratory disorder22.02.07.0020.000849%Not Available
Restlessness17.02.05.021; 19.11.02.0020.000849%
Rhinorrhoea22.02.05.0100.001273%
Sepsis11.01.11.0030.000332%
Shock24.06.02.002--Not Available
Skin necrosis23.03.03.0110.002122%Not Available
Skin reaction23.03.03.013; 10.01.03.0190.000849%Not Available
Skin ulcer24.04.03.007; 23.07.03.0030.000849%
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