Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ileus07.13.01.0010.000390%
Immune system disorder10.02.01.001--Not Available
Increased tendency to bruise24.07.06.012; 23.06.01.009; 01.01.03.0050.000633%Not Available
Inguinal hernia07.16.02.0010.000369%Not Available
Injection site haematoma24.07.01.009; 12.07.03.004; 08.02.03.004--Not Available
Intermittent claudication24.04.03.0010.000117%Not Available
Interstitial lung disease22.01.02.003; 10.02.01.0330.002560%Not Available
Intestinal infarction24.04.08.008; 07.15.02.0060.000043%Not Available
Intestinal ischaemia24.04.08.001; 07.15.02.0010.000369%Not Available
Intestinal stenosis07.13.01.0030.000043%Not Available
Intracranial aneurysm24.02.04.001; 17.08.06.0010.000291%Not Available
Intraventricular haemorrhage24.07.04.008; 17.08.01.0170.001440%Not Available
Iron deficiency14.13.02.0020.000286%Not Available
Iron deficiency anaemia14.13.02.001; 01.03.01.0020.000907%Not Available
Jaundice cholestatic09.01.01.0050.000130%Not Available
Lactose intolerance14.02.02.001; 07.17.01.0030.000369%Not Available
Large intestinal ulcer07.04.06.0040.000043%
Lip dry07.06.01.003--Not Available
Listless19.04.04.003; 08.01.01.0120.000065%Not Available
Livedo reticularis23.06.05.001; 24.03.04.0030.000043%Not Available
Liver function test abnormal13.03.04.030--Not Available
Loss of consciousness17.02.04.004--Not Available
Macular degeneration06.09.03.0010.000412%Not Available
Macule23.03.03.0370.000169%Not Available
Malabsorption14.02.01.004; 07.17.01.001--
Mallory-Weiss syndrome24.07.02.038; 07.12.01.0040.000239%Not Available
Marasmus14.03.02.0130.000174%Not Available
Mass08.03.05.0030.000499%Not Available
Melaena24.07.02.013; 07.12.02.0040.004842%Not Available
Menometrorrhagia21.01.03.001--Not Available
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