Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. It has also been used to lower the risk of developing venous thrombosis post-orthopedic surgical procedures.
Marketing Status Prescription
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 65129-1344; 55111-980; 50193-0893; 63629-8432; 16436-0113; 70366-001; 46708-908; 52048-0420; 63850-8085; 42816-0893; 14445-150; 59651-051; 53747-062; 65015-897; 55154-0613; 66174-0091; 76397-007; 75945-060; 24196-190; 15308-1221; 12783-0894; 66651-921; 63415-0520; 70518-1861; 66039-925; 65372-1196; 55154-0612; 12783-0893; 69989-0006; 76397-010; 42765-025; 76072-1017; 14501-0089; 67835-0015; 69037-0023; 50090-1437; 0003-0894; 58623-0137; 0003-3764; 42816-0894; 67296-1673; 58032-2028; 50090-1436; 65727-081; 14445-014; 63629-7747; 14445-149
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
General physical condition abnormal13.15.01.040--Not Available
Thalamus haemorrhage24.07.04.033; 17.08.01.0620.000657%Not Available
Putamen haemorrhage24.07.04.031; 17.08.01.0580.000265%Not Available
Haemorrhagic cyst24.07.01.069; 16.02.02.013; 08.03.05.0080.000265%Not Available
Intracranial haematoma24.07.04.027; 17.08.01.0510.000242%Not Available
Gastrointestinal erosion07.04.04.0090.000265%Not Available
Embolic cerebral infarction24.01.04.009; 17.08.01.0290.000311%Not Available
Trousseau's syndrome24.01.01.033; 16.32.03.0280.000397%Not Available
Appendix disorder07.11.01.0200.000397%Not Available
Arterial haemorrhage24.07.01.0630.001060%Not Available
Arterial stenosis24.04.02.0120.000265%Not Available
Cerebellar haematoma24.07.04.022; 17.08.01.0450.000242%Not Available
Communication disorder19.19.01.0080.000530%Not Available
Escherichia infection11.02.10.004--Not Available
Foot deformity15.10.03.005--Not Available
Malignant peritoneal neoplasm16.13.04.005; 07.21.03.0050.000069%Not Available
Skull fracture15.08.04.002; 12.04.05.0030.000311%Not Available
Traumatic intracranial haemorrhage24.07.04.034; 17.08.05.005; 12.01.10.0170.000933%Not Available
Tricuspid valve disease02.07.05.0040.000265%
Aortic valve disease02.07.03.0020.002385%
Angiodysplasia24.03.03.0170.000397%Not Available
Carotid artery disease24.03.05.009; 17.08.02.0160.000795%Not Available
Salivary gland cancer16.13.12.001; 07.21.07.0080.000265%Not Available
Erosive duodenitis07.04.02.0060.000397%Not Available
Tracheal haemorrhage24.07.01.084; 22.04.07.009; 12.02.07.0130.000104%
Endocarditis noninfective02.09.01.0030.000397%Not Available
Bladder tamponade24.07.01.064; 20.02.02.0240.000397%Not Available
Thoracic haemorrhage24.07.01.082; 22.02.07.0170.000795%Not Available
Chronic left ventricular failure02.05.02.0060.000104%Not Available
Microscopic polyangiitis24.05.02.021; 20.05.01.017; 10.02.02.0250.000265%Not Available
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