Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Colitis ischaemic24.04.08.012; 07.08.01.0040.000390%Not Available
Colon cancer16.13.01.001; 07.21.01.0010.001106%Not Available
Compartment syndrome15.05.05.005; 24.04.05.0060.000195%Not Available
Conjunctival haemorrhage24.07.05.001; 06.07.01.0010.000486%Not Available
Convulsions local17.12.03.0090.000043%Not Available
Cor pulmonale24.08.03.001; 22.06.01.003; 02.05.03.0010.000043%Not Available
Coronary artery disease24.04.04.006; 02.02.01.0010.000586%Not Available
Coronary artery stenosis12.02.01.037; 24.04.04.017; 02.02.01.0100.000108%Not Available
Cutaneous vasculitis24.12.04.008; 23.06.02.001; 10.02.02.0030.000226%Not Available
Cystitis haemorrhagic20.03.02.0030.000195%Not Available
Death08.04.01.0010.054958%
Decubitus ulcer23.03.11.0060.000152%Not Available
Dementia19.20.02.001; 17.03.01.0010.002495%Not Available
Dementia Alzheimer's type17.03.06.001; 19.20.03.0010.000260%Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis allergic10.01.03.014; 23.03.04.0030.000725%Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diabetic retinopathy24.03.07.004; 14.07.01.002; 06.10.02.002; 05.07.01.0020.000043%Not Available
Diarrhoea haemorrhagic24.07.02.004; 07.02.01.0020.000174%Not Available
Disseminated intravascular coagulation24.01.01.010; 01.01.02.0020.000456%
Diverticulum07.10.01.0010.000542%Not Available
Diverticulum intestinal07.10.01.0020.000282%Not Available
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Drug hypersensitivity10.01.01.001--Not Available
Drug interaction08.06.03.001--Not Available
Duodenal ulcer07.04.02.0020.001128%
Duodenal ulcer haemorrhage24.07.02.020; 07.04.02.0040.000260%Not Available
Duodenitis07.08.03.0010.000195%Not Available
Dysarthria19.19.03.001; 17.02.08.001--
Dysphagia07.01.06.0030.005588%
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