Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cerebral ventricle dilatation17.11.01.0130.000087%Not Available
Basilar artery occlusion24.04.06.030; 17.08.01.0420.000043%Not Available
Vertebral artery occlusion24.04.06.043; 17.08.01.0640.000043%Not Available
Neck mass15.03.02.0070.000169%Not Available
Subclavian vein thrombosis24.01.02.0130.000152%Not Available
Tongue haemorrhage07.14.01.015; 24.07.02.0580.000117%Not Available
Mediastinal haematoma24.07.01.074; 22.09.03.0070.000065%Not Available
Spinal subdural haematoma24.07.04.032; 17.08.01.060; 12.01.13.0080.000130%Not Available
Gastric antral vascular ectasia24.03.03.028; 07.15.04.0030.000095%Not Available
Small intestinal haemorrhage24.07.02.019; 07.12.03.0020.000434%
Meningorrhagia24.07.04.030; 17.08.01.056; 12.01.10.0160.000065%Not Available
Cardiac ventricular thrombosis02.11.01.008; 24.01.05.0060.000347%Not Available
Small intestine carcinoma16.13.13.002; 07.21.01.0160.000043%Not Available
Breast cancer metastatic16.10.01.008; 21.05.01.0160.000282%Not Available
Colon cancer metastatic16.13.01.012; 07.21.01.0100.000130%Not Available
Factor V inhibition01.01.02.0200.000087%Not Available
Gastrointestinal mucosal disorder07.11.03.0080.000043%Not Available
Hepatic mass09.01.08.0150.000065%Not Available
Peripheral artery occlusion24.04.03.0220.000217%Not Available
Ovarian cancer metastatic21.11.01.013; 16.12.04.0040.000043%Not Available
Cardiac perforation12.02.01.020; 02.11.01.0060.000065%Not Available
Hypertensive emergency24.08.01.0040.000065%Not Available
Bladder mass20.03.01.0180.000087%Not Available
Thalamus haemorrhage24.07.04.033; 17.08.01.0620.000564%Not Available
Putamen haemorrhage24.07.04.031; 17.08.01.0580.000043%Not Available
Haemorrhagic cyst24.07.01.069; 16.02.02.013; 08.03.05.0080.000065%Not Available
Intracranial haematoma24.07.04.027; 17.08.01.0510.000217%Not Available
Non-small cell lung cancer metastatic22.08.01.021; 16.19.01.0090.000043%Not Available
Renal cyst haemorrhage24.07.07.003; 20.01.04.017; 16.27.01.0050.000043%Not Available
Gastrointestinal erosion07.04.04.0090.000065%Not Available
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