Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Macular hole06.09.03.0090.000043%Not Available
Post procedural haemorrhage24.07.01.014; 12.02.05.004--
Lacunar infarction24.04.06.009; 17.08.01.0160.000174%Not Available
Catheter site haemorrhage24.07.01.003; 12.07.02.002; 08.02.02.0020.000499%Not Available
Incision site haemorrhage24.07.01.022; 12.02.05.014--Not Available
Puncture site haemorrhage24.07.01.034; 12.07.04.006; 08.02.04.0070.000065%Not Available
Facial paresis17.04.03.0020.000195%
Bile duct stenosis09.02.02.0010.000043%
Wound haemorrhage12.01.08.017; 24.07.01.029--Not Available
Large intestine polyp16.05.02.006; 07.20.01.0100.001085%Not Available
Acute coronary syndrome02.02.02.015; 24.04.04.0110.000868%Not Available
Haemodynamic instability24.03.02.0060.000239%Not Available
Oesophageal rupture12.01.17.015; 07.04.05.0050.000043%Not Available
Lymphatic disorder01.09.01.003--Not Available
Colorectal adenocarcinoma16.13.01.009; 07.21.01.0070.000043%Not Available
Large intestinal haemorrhage24.07.02.026; 07.12.03.0030.000477%
Cardiac flutter02.03.02.0120.000108%Not Available
Organ failure08.01.03.0410.000087%Not Available
Traumatic haemorrhage24.07.01.056; 12.01.08.029--Not Available
Vascular occlusion24.04.02.0150.000087%Not Available
Acquired haemophilia01.01.01.0020.000152%Not Available
Cerebral haematoma24.07.04.006; 17.08.01.0140.001085%Not Available
Haemorrhoidal haemorrhage24.10.02.001; 07.15.03.0020.001449%
Transaminases increased13.03.04.036--Not Available
Cerebral disorder17.02.10.0170.000217%Not Available
Pelvic haematoma24.07.03.010; 21.07.04.0010.000182%Not Available
Haemorrhagic transformation stroke24.07.04.018; 17.08.01.0360.000260%Not Available
Haemorrhage24.07.01.0020.030206%Not Available
Haemorrhage urinary tract24.07.01.007; 20.02.03.0050.000659%Not Available
Postmenopausal haemorrhage24.07.03.002; 21.02.01.0020.000108%Not Available
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